ArticleGut1995
Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Expression of CD44v6 and RCAS1 in Uterine Cervical Carcinoma Infected with Human Papillomavirus and Its Effect on Cell Proliferation and Differentiation.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Hp-Positive Chinese Patients Should Undergo Colonoscopy Earlier and More Frequently: The Result of a Cross-Sectional Study Based on 13,037 Cases of Gastrointestinal Endoscopy.Frontiers in oncology · 2021Article
- CD44v6 engages in colorectal cancer progression.Cell death & disease · 2019Review
- Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer : future possibilities for personalised treatment by use of biomarkers.Virchows Archiv : an international journal of pathology · 2012Review
- Colon cancer stem cells: implications in carcinogenesis.Frontiers in bioscience (Landmark edition) · 2011Review
- Immunohistochemical analyses of E-cadherin, beta-catenin, CD44s, and CD44v6 expressions, and Ki-67 labeling index in intraductal papillary mucinous neoplasms of the pancreas and associated invasive carcinomas.Medical molecular morphology · 2009Article
- Endothelial adhesion of synchronized gastric tumor cells changes during cell cycle transit and correlates with the expression level of CD44 splice variants.World journal of gastroenterology · 2005Article
- Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2004Article
- Expression of CD44s in human colorectal cancer.Pathology oncology research : POR · 2002Article
- The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas.British journal of cancer · 2001Article
- Limitations of CD44v6 amplification for the detection of tumour cells in the blood of colorectal cancer patients.British journal of cancer · 2000Article
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- Expression of A and H blood-group and of CD44 antigens during chemical rat colonic carcinogenesis.Glycoconjugate journal · 1997Article
- CD44 and the adhesion of neoplastic cells.Molecular pathology : MP · 1997Review
- Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer.British journal of cancer · 1996Article
- Increased expression of CD44v6 in endocrine pancreatic tumours but not in midgut carcinoid tumours.Clinical molecular pathology · 1996Article
- The positive relationship between the expression of CD44 variant 6 and prognosis in colorectal cancer.Surgery today · 1996Article
- Relation between stage, grade, proliferation, and expression of p53 and CD44 in adenomas and carcinomas of the colorectum.Journal of clinical pathology · 1995Article
- Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma.British journal of cancer · 1995Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n = 12), late adneomas (n = 12), Dukes's A and B carcinomas (n = 21), and Dukes's C and D carcinomas (n = 22) and compared these results with expression of these proteins in normal colonic mucosa (n = 17). A statistically significant trend of increasing expression was seen for both p53 (p < 0.005) and CD44 variant exon v6 (p < 0.0005) in subsequent stages of this tumour progression model. High expression of CD44 v5 was seen in most colorectal neoplasms (83%-96%), independent of stage. A statistically significant correlation was present between p53 expression and expression of variant v6 of CD44 (p < 0.01). Both p53 expression and CD44 v6 expression in adenomas increased with the degree of dysplasia (p < 0.05). The results of this study show that mutant p53 protein and variant v6 of the CD44 glycoprotein are markers of tumour progression in colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.