ArticleThe Journal of clinical investigation1995
Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review.Haematologica · 2013Pooled it
- Characterization of human IgM and IgG repertoires in individuals with chronic HIV-1 infection.Virologica Sinica · 2022Article
- A Posttranscriptional Pathway of CD40 Ligand mRNA Stability Is Required for the Development of an Optimal Humoral Immune Response.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Hyper IgM Syndrome: a Report from the USIDNET Registry.Journal of clinical immunology · 2016Article
- Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.The Journal of clinical investigation · 2006Article
- Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications.British journal of cancer · 2003Article
- Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.The Journal of clinical investigation · 2001Article
- CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome.The Journal of clinical investigation · 1999Article
- Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome.The Journal of clinical investigation · 1998Article
- Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase.Clinical and experimental immunology · 1998Article
- The hyper-IgM (HIM) syndrome.Springer seminars in immunopathology · 1998Review
- Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.The Journal of clinical investigation · 1997Article
- Memory B lymphocytes migrate to bone marrow in humans.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.The Journal of experimental medicine · 1996Article
- Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.The EMBO journal · 1996Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Somatic mutation of Ig variable regions occurs prominently in germinal centers, but it has been debated whether the mutation process initiates in germinal centers or is activated before germinal center entry of B cells. We have analyzed for the presence of somatic mutation in Ig gene rearrangements of the nonpolymorphic human VH6 gene in the X-linked HyperIgM syndrome, which is associated with defective CD40 ligand expression and absence of germinal centers and generation of memory B lymphocytes. IgM and rare IgG VH6 productive rearrangements were isolated from PBL of patients with X-linked HyperIgM syndrome. Although the majority of both the IgM and IgG VH6 rearrangements had a germline VH6 sequence, 7 of 102 VH6 IgM and 1 of 6 IgG rearrangements had a mutated VH6 gene. The mutation frequency (mutations/bp) was 1.4% with a range of 2-9 mutations per clone, a mutation frequency lower, however, than that observed in IgM (3.2%) and IgG (5.4%) VH6 rearrangements of normal individuals. These results suggest that somatic mutation may be initiated in a CD40 ligand-independent pathway before entry of B cells into germinal centers, but fails to achieve the high mutation frequency observed in the presence of germinal centers.
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