ArticleThe Journal of experimental medicine1995
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 106 citations in OpenAlex.
- Meant to B: B cells as a therapeutic target in systemic lupus erythematosus.The Journal of clinical investigation · 2021Review
- Loss of an IgG plasma cell checkpoint in patients with lupus.The Journal of allergy and clinical immunology · 2019Article
- Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.Cell reports · 2016Article
- Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.Autoimmunity · 2013Article
- TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.Autoimmunity · 2013Article
- Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.The Journal of experimental medicine · 2012Article
- Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens.Arthritis and rheumatism · 2012Article
- Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus.PloS one · 2009Article
- Antigen-induced B cell apoptosis is independent of complement C4.Clinical and experimental immunology · 2007Article
- Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors.Seminars in immunology · 2007Review
- Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.The Journal of experimental medicine · 2006Article
- Autoreactive responses to an environmental factor. 2. Phthalate-induced anti-DNA specificity is downregulated by autoreactive cytotoxic T cells.Immunology · 2004Article
- Maintenance and loss of self-tolerance in B cells.Springer seminars in immunopathology · 2001Review
- Contributions of antibody VH domains to anti-DNA autoreactivity.Clinical reviews in allergy & immunology · 2000Review
- Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.The Journal of experimental medicine · 1999Article
- Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.The Journal of experimental medicine · 1999Article
- MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells.The Journal of experimental medicine · 1999Article
- Regulation of autoreactive anti-IgG (rheumatoid factor) B cells in normal and autoimmune mice.Immunologic research · 1999Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Anti-DNA antibodies, specifically those that stain nuclei in a homogenous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model. We have used a heavy chain transgene that increases the frequency of anti-HN antibodies to address whether their production in SLE is the consequence of a defect in B cell tolerance. Anti-HN B cells were undetectable in nonautoimmune-prone transgenic mice, but in MRL-lpr/lpr transgenic mice their Ig was evident in the sera and they were readily retrievable as hybridomas. We conclude that nonautoimmune animals actively delete anti-HN-specific B cells, and that MRL-lpr/lpr mice are defective in this process possibly because of the lpr defect in the fas gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.