Trial reportThe Journal of clinical investigation1995
Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.
Trial report in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 226 citations in OpenAlex.
- Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?Clinical reviews in allergy & immunology · 2024Review
- Recent advances in epicutaneous immunotherapy and potential applications in food allergy.Frontiers in allergy · 2023Review
- Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?Nature reviews. Immunology · 2021Review
- Epigenetic alterations in skin homing CD4Scientific reports · 2020Article
- Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies.Bioscience reports · 2020Review
- Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy.Clinical and experimental immunology · 2018Article
- In-vitro diagnostic in atopic dermatitis: Options and limitations.Allergologie select · 2017Review
- Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.The Journal of allergy and clinical immunology · 2015Article
- Clinical spectrum of food allergies: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
- Food hypersensitivity in patients with childhood atopic dermatitis in Korea.Annals of dermatology · 2013Article
- T cell homing to epithelial barriers in allergic disease.Nature medicine · 2012Review
- [Food allergy in atopic dermatitis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2012Article
- Food allergy and atopic dermatitis: how are they connected?Current allergy and asthma reports · 2011Article
- Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin.The Journal of clinical investigation · 2011Article
- Therapeutic manipulation of immune tolerance in allergic disease.Nature reviews. Drug discovery · 2009Review
- The role of food allergy in atopic dermatitis.Current allergy and asthma reports · 2008Review
- Early detection of allergic diseases in otorhinolaryngology.GMS current topics in otorhinolaryngology, head and neck surgery · 2008Article
- Role of bacterial pathogens in atopic dermatitis.Clinical reviews in allergy & immunology · 2007Review
- Nonimmunoglobulin e-mediated immune reactions to foods.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2006Article
- Immune surveillance in the skin: mechanisms and clinical consequences.Nature reviews. Immunology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The extravasation of T cells at sites of inflammation is critically dependent on the activity of homing receptors (HR) involved in endothelial cell recognition and binding. Two such HR (the cutaneous lymphocyte antigen [CLA] and L-selectin) have been shown to be selectively involved in T cell migration to skin and peripheral lymph nodes, respectively. This study was designed to assess the relationship between the organ specificity of an allergic reaction to food and the expression of HR on T cells activated in vitro by the relevant food allergen. Peripheral blood mononuclear cells were isolated from seven milk allergic children with a history of eczema when exposed to milk. All patients had a positive prick skin test and double-blind placebo-controlled food challenge to milk. 10 children with either allergic eosinophilic gastroenteritis or milk-induced enterocolitis and 8 nonatopic adults served as controls. Five-parameter flow cytometry using monoclonal antibodies was used for detection of the specific HR on freshly isolated T cells versus T cell blasts induced by a 6-d incubation with casein, as compared with Candida albicans. After in vitro stimulation with casein, but not C. albicans, patients with milk allergy and atopic dermatitis had a significantly greater percentage of CLA+ T cells (P < 0.01) than controls with milk-induced enterocolitis, allergic eosinophilic gastroenteritis, or nonatopic healthy controls. In contrast, the percentage of L-selectin-expressing T cells did not differ significantly between these groups. These data suggest that after casein stimulation allergic patients with milk-induced skin disease have an expanded population of CLA+ T cells, as compared with nonatopics or allergic patients without skin involvement. We postulate that heterogeneity in the regulation of HR expression on antigen-specific T cells may play a role in determining sites of involvement in tissue-directed allergic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.