ArticleCurrent genetics1994
Nitrogen, carbon, and pH regulation of extracellular acidic proteases of Aspergillus niger.
Article in Current genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 90 citations in OpenAlex.
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
- Genome-wide high-throughput signal peptide screening via plasmid pUC256E improves protease secretion in Lactiplantibacillus plantarum and Pediococcus acidilactici.BMC genomics · 2022Article
- Glucose-Mediated Repression of Plant Biomass Utilization in the White-Rot FungusApplied and environmental microbiology · 2019Article
- A Major Facilitator Superfamily Peptide Transporter FromFrontiers in microbiology · 2019Article
- Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites.G3 (Bethesda, Md.) · 2015Article
- A genomic survey of proteases in Aspergilli.BMC genomics · 2014Article
- The molecular components of the extracellular protein-degradation pathways of the ectomycorrhizal fungus Paxillus involutus.The New phytologist · 2013Article
- Article
- Fungal proteases and their pathophysiological effects.Mycopathologia · 2011Review
- Production of Proteolytic Enzymes by a Keratin-Degrading Aspergillus niger.Enzyme research · 2011Article
- Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus.Infection and immunity · 2009Article
- Expression of the nitrate transporter nrt2 gene from the symbiotic basidiomycete Hebeloma cylindrosporum is affected by host plant and carbon sources.Mycorrhiza · 2009Article
- The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation.Current genetics · 2008Article
- Multi-factor regulation of pectate lyase secretion by Colletotrichum gloeosporioides pathogenic on avocado fruits.Molecular plant pathology · 2008Article
- Cuticle-degrading proteases produced by the entomopathogenic fungus Beauveria bassiana in the presence of coffee berry borer cuticle.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2008Article
- Metabolically independent and accurately adjustable Aspergillus sp. expression system.Applied and environmental microbiology · 2005Article
- Regulation of gene expression by ambient pH in filamentous fungi and yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Silencing of the aspergillopepsin B (pepB) gene of Aspergillus awamori by antisense RNA expression or protease removal by gene disruption results in a large increase in thaumatin production.Applied and environmental microbiology · 2002Article
- Aspergillus enzymes involved in degradation of plant cell wall polysaccharides.Microbiology and molecular biology reviews : MMBR · 2001Review
- Opposite patterns of expression of two Aspergillus nidulans xylanase genes with respect to ambient pH.Journal of bacteriology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus niger secretes a number of enzymes, including proteases, into its culture fluid. The regulation of the two major acidic extracellular proteases, pepA and pepB, was investigated using Northern analyses. Our data suggest that the regulation of pepA and pepB expression occurs predominantly at the level of mRNA content and that, while they are regulated in a similar manner, differences are also clear in their expression. Both genes were found to be under complex regulatory control. The expression of the two genes could be turned off by the presence of good nitrogen or carbon sources in the media, and external protein sources did not induce expression of either gene under conditions of carbon and nitrogen repression. The pH of the medium also played a major role in their regulation as the expression of both genes was completely turned off under alkaline conditions, even when grown in media lacking good nitrogen and carbon sources but containing proteins. We isolated clones containing 5' non-coding sequences of the pepA gene from a lambda genomic library with a pepA specific probe. Analysis and comparison of the promoter sequences of the pepA and pepB genes revealed that both contain several putative AREA- and CREA-binding sites and they also share an 18-bp-long sequence which is 83% identical in these two genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.