ArticleThe American journal of pathology1995
Identification of tissue-infiltrating lymphocytes expressing PEN5, a mucin-like glycoprotein selectively expressed on natural killer cells.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals.Cellular and molecular life sciences : CMLS · 2011Review
- Analysis of islet inflammation in human type 1 diabetes.Clinical and experimental immunology · 2009Article
- Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus.Journal of virology · 2002Article
- Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The PEN5 epitope identifies an oligodendrocyte precursor cell population and pilocytic astrocytomas.The American journal of pathology · 1999Article
- Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.The American journal of pathology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
PEN5 is a carbohydrate epitope selectively expressed on peripheral blood natural killer cells. We have used a monoclonal antibody reactive with PEN5 to survey the expression of PEN5+ large granule lymphocytes in a variety of human tissues. PEN5+ cells are scattered throughout lymphoid (eg, lymph node, tonsil, thymus, spleen, and intestine) and nonlymphoid (eg, liver, esophagus, lung, and uterus) organs. Due to their relatively abundant cytoplasm, these cells are somewhat larger than resting tissue lymphocytes. The majority of splenic (87 +/- 13%, n = 5) and hepatic (92 +/- 6%, n = 5) PEN5+ lymphocytes coexpress TIA-1, a cytotoxic granule protein found in natural killer cells. In some tissues (eg, tonsil and Peyer's patch), however, relatively few PEN5+ lymphocytes coexpress TIA-1, possibly reflecting different stages of activation or differentiation. Our results indicate that PEN5 may be a useful marker of tissue-infiltrating natural killer cells and reveal these cells to be surprisingly abundant in lymphoid tissues.
Indexed as
Identifiers
7531954PMC1869861W52977401What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.