ArticleBritish journal of cancer1995
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 137 citations in OpenAlex.
- Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma.Biomolecules · 2022Review
- Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk.Clinical and translational medicine · 2018Article
- TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.Experimental cell research · 2015Article
- Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer.Cancer gene therapy · 2014Review
- Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.Physiological reviews · 2011Review
- Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition.Molecular and cellular biology · 2010Article
- Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.Journal of cell science · 2006Article
- Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline.British journal of cancer · 2005Article
- Redistribution of β-catenin in response to EGF and lithium signalling in human oesophageal squamous carcinoma cell lines.Cancer cell international · 2003Article
- IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition.Oncogene · 2001Article
- Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?Molecular pathology : MP · 1999Review
- The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.Oncogene · 1999Article
- Co-expression of E-cadherin and alpha-catenin molecules in colorectal cancer.Surgery today · 1999Article
- The role of adhesion molecules in gastric ulcer healing.World journal of gastroenterology · 1998Article
- E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).The Journal of cell biology · 1998Article
- Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer.British journal of cancer · 1998Article
- Primary human fibroblasts induce diverse tumor invasiveness: involvement of HGF as an important paracrine factor.Japanese journal of cancer research : Gann · 1996Article
- E-cadherin relates to EGFR expression and lymph node metastasis in primary breast carcinoma.British journal of cancer · 1996Article
- Inverse correlation between mRNA expression of plasminogen activator inhibitor-2 and lymph node metastasis in human breast cancer.Japanese journal of cancer research : Gann · 1996Article
- Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermal growth factor (EGF) mediates many pleiotrophic biological effects, one of which is alteration of cellular morphology. In the present study, we examine the possibility that this alteration in cell morphology is caused in part by the dysfunction of cadherin-mediated cell-cell adhesion using the human oesophageal cancer cell line TE-2R, which expresses E-cadherin and EGF receptor. In the presence of EGF, TE-2R changed its shape from round to fibroblastic and its colony formation from compact to sparse. Vanadate, a tyrosine phosphatase inhibitor, further potentiated the EGF response, whereas herbimycin A, a tyrosine kinase inhibitor, interfered with it. Moreover, EGF enabled the cells to invade in organotypic raft culture. These phenomena were accompanied not by decreased expression of the E-cadherin molecule but by a change in its localisation from the lateral adhesion site to the whole cell surface. Both alpha- and beta-catenin, cadherin-binding proteins, were also expressed at the same level throughout these morphological changes. Finally, we examined tyrosine phosphorylation of E-cadherin and alpha- and beta-catenin, and observed tyrosine phosphorylation of beta-catenin induced by EGF. These results suggest that EGF counteracts E-cadherin-mediated junctional assembly through phosphorylation of beta-catenin and modulates tumour cell behaviour to a more aggressive phenotype.
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