ArticleThe Journal of experimental medicine1995
Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 335 citations in OpenAlex.
- Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Nitric Oxide to Fight Viral Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight.Metabolites · 2020Review
- CCR5 is a required signaling receptor for macrophage expression of inflammatory genes in response to viral double-stranded RNA.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Nitric Oxide Influences HSV-1-Induced Neuroinflammation.Oxidative medicine and cellular longevity · 2019Article
- Role of nitric oxide in immune responses against viruses: beyond microbicidal activity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Detection of nitric oxide production in cell cultures by luciferin-luciferase chemiluminescence.Biochemical and biophysical research communications · 2015Article
- Macrophage Expression of Inflammatory Genes in Response to EMCV Infection.Biomolecules · 2015Review
- The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders.Frontiers in microbiology · 2015Review
- Oxidative stress and the HIV-infected brain proteome.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Redox pioneer: Professor Stuart A. Lipton.Antioxidants & redox signaling · 2013Article
- HIV Associated Neurocognitive Disorders.Infectious disease reports · 2013Review
- Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman"?Reviews in medical virology · 2012Review
- Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.PloS one · 2012Article
- Screening assay for oxidative stress in a feline astrocyte cell line, G355-5.Journal of visualized experiments : JoVE · 2011Article
- Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.The American journal of pathology · 2010Article
- Free radical generation by neurons in rat model of Japanese encephalitis.Neurochemical research · 2009Article
- Enhancement of neuronal outward delayed rectifier K+ current by human monocyte-derived macrophages.Glia · 2009Article
- Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis.Virology journal · 2009Article
- Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes.AIDS research and human retroviruses · 2009Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Mononuclear phagocytes (monocytes, macrophages, and dendritic cells) play major roles in human immunodeficiency virus (HIV) persistence and disease pathogenesis. Macrophage antigen presentation and effector cell functions are impaired by HIV-1 infection. Abnormalities of macrophage effector cell function in bone marrow, lung, and brain likely result as a direct consequence of cellular activation and HIV replication. To further elucidate the extent of macrophage dysfunction in HIV-1 disease, a critical activation-specific regulatory molecule, nitric oxide (NO.), which may contribute to diverse pathology, was studied. Little, if any, NO. is produced by uninfected human monocytes. In contrast, infection with HIV-1 increases NO. production to modest, but significant levels (2-5 microM). Monocyte activation (with lipopolysaccharide, tumor necrosis factor alpha, or through interactions with astroglial cells) further enhances NO. production in HIV-infected cells, whereas its levels are diminished by interleukin 4. These results suggest a possible role for NO. in HIV-associated pathology where virus-infected macrophages are found. In support of this hypothesis, RNA encoding the inducible NO synthase (iNOS) was detected in postmortem brain tissue from one pediatric AIDS patient with advanced HIV encephalitis. Corresponding iNOS mRNA was not detected in brain tissue from five AIDS patients who died with less significant brain disease. These results demonstrate that HIV-1 can influence the expression of NOS in both cultured human monocytes and brain tissue. This newly described feature of HIV-macrophage interactions suggests previously unappreciated mechanisms of tissue pathology that result from productive viral replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.