ArticleThe Biochemical journal1995
Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- Fc receptors act as innate immune receptors during infection?Frontiers in immunology · 2023Review
- Equus β-Defensin-1 Regulates Innate IMMUNE Response inAnimals : an open access journal from MDPI · 2022Article
- Kinase Inhibition as Treatment for Acute and Chronic Graft-Frontiers in immunology · 2021Review
- Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population.Frontiers in immunology · 2020Review
- Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses.Frontiers in immunology · 2019Review
- How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis.Frontiers in immunology · 2019Review
- CD32 Ligation Promotes the Activation of CD4Frontiers in immunology · 2018Article
- Review
- FcγRIIa requires lipid rafts, but not co-localization into rafts, for effector function.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels.Leukemia · 2012Article
- Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis.Archives of biochemistry and biophysics · 2011Review
- Interaction of two phagocytic host defense systems: Fcγ receptors and complement receptor 3.The Journal of biological chemistry · 2011Article
- Differential requirement of lipid rafts for FcγRIIA mediated effector activities.Cellular immunology · 2010Article
- Fcgamma receptors: structure, function and role as genetic risk factors in SLE.Genes and immunity · 2009Review
- Fcgamma receptor signaling in phagocytes.International journal of hematology · 2006Review
- Recruitment of the cross-linked opsonic receptor CD32A (FcgammaRIIA) to high-density detergent-resistant membrane domains in human neutrophils.The Biochemical journal · 2004Article
- Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Cytokine responses of human blood monocytes stimulated with Igs.Inflammation · 1997Article
- Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.The Journal of experimental medicine · 1996Article
- In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.Molecular and cellular biology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although the cytoplasmic portion of the low-affinity receptor for immunoglobulin G, Fc gamma RII, does not contain a kinase domain, rapid tyrosine phosphorylation of intracellular substrates occurs in response to aggregation of the receptor. The use of specific tyrosine kinase inhibitors has suggested that these phosphorylations are required for subsequent cellular responses. We previously demonstrated the coprecipitation of a tyrosine kinase activity with Fc gamma RII, suggesting that non-receptor tyrosine kinases might associate with the cytoplasmic domain of Fc gamma RII. Anti-receptor immune complex kinase assays revealed the coprecipitation of several phosphoproteins, most notably p56/53lyn, an Src-family protein tyrosine kinase (PTK), and a 72 kDa phosphoprotein. Here we identify the 72 kDa Fc gamma RII-associated protein as p72syk (Syk), a member of a newly described family of non-receptor PTKs. A rapid and transient tyrosine phosphorylation of Syk was observed following Fc gamma RII activation. Syk was also tyrosyl-phosphorylated following aggregation of the high-affinity Fc gamma receptor, Fc gamma RI. The Fc gamma RI activation did not result in association of Syk with Fc gamma RII, implying that distinct pools of Syk are activated upon aggregation of each receptor in a localized manner. These results demonstrate a physical association between Syk and Fc gamma RII and suggest that the molecules involved in Fc gamma RII signalling are very similar to the ones utilized by multichain immune recognition receptors such as the B-cell antigen receptor and the high-affinity IgE receptor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.