ArticlePlant physiology1994
Cyclic AMP stimulates K+ channel activity in mesophyll cells of Vicia faba L.
Article in Plant physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices.International journal of molecular sciences · 2024Review
- Plant adenylate cyclases have come full circle.Nature plants · 2023Review
- Functional Crypto-Adenylate Cyclases Operate in Complex Plant Proteins.Frontiers in plant science · 2021Article
- Cyclic AMP: A Polyhedral Signalling Molecule in Plants.International journal of molecular sciences · 2020Review
- TheFrontiers in plant science · 2018Article
- Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling.Frontiers in plant science · 2017Review
- Cyclic AMP deficiency negatively affects cell growth and enhances stress-related responses in tobacco Bright Yellow-2 cells.Plant molecular biology · 2016Article
- Heterotrimeric G protein-coupled signaling in plants.Annual review of plant biology · 2014Review
- Molecular steps in the immune signaling pathway evoked by plant elicitor peptides: Ca2+-dependent protein kinases, nitric oxide, and reactive oxygen species are downstream from the early Ca2+ signal.Plant physiology · 2013Article
- cAMP activates hyperpolarization-activated Ca2+ channels in the pollen of Pyrus pyrifolia.Plant cell reports · 2011Article
- Adenyl cyclases and cAMP in plant signaling - past and present.Cell communication and signaling : CCS · 2010Article
- Involvement of cAMP signaling in elicitor-induced phytoalexin accumulation in Cupressus lusitanica cell cultures.The New phytologist · 2004Article
- Differences in whole-cell and single-channel ion currents across the plasma membrane of mesophyll cells from two closely related Thlaspi species.Plant physiology · 2003Article
- Electrophysiological analysis of cloned cyclic nucleotide-gated ion channels.Plant physiology · 2002Article
- Sodium uptake in Arabidopsis roots is regulated by cyclic nucleotides.Plant physiology · 2001Article
- Malate-permeable channels and cation channels activated by aluminum in the apical cells of wheat roots.Plant physiology · 2001Article
- Cloning and first functional characterization of a plant cyclic nucleotide-gated cation channel.Plant physiology · 1999Article
- Rundown of the hyperpolarization-activated KAT1 channel involves slowing of the opening transitions regulated by phosphorylation.Biophysical journal · 1999Article
- cGMP Is Required for Gibberellic Acid-Induced Gene Expression in Barley Aleurone.The Plant cell · 1996Article
- Membrane-Delimited Phosphorylation Enables the Activation of the Outward-Rectifying K Channels in Motor Cell Protoplasts of Samanea saman.Plant physiology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Whole-cell patch-clamp recordings from Vicia faba mesophyll protoplasts reveal that outward K+ current is increased in a dose-dependent fashion by intracellular application of cAMP. The enhancement of the outward current by cAMP is specific and it cannot be mimicked by a series of nucleotides that includes AMP, cGMP, and GMP. The enhancement is evoked by micromolar concentrations of cAMP in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine. PKI or Walsh inhibitor, a specific peptide inhibitor of cAMP-dependent protein kinase (PKA), inhibits the outward K+ current. Adenosine 3',5'-phosphothioate, a competitive inhibitor of PKA, has a similar effect. Conversely, the catalytic subunit of PKA (cAMP independent) from bovine brain enhances the magnitude of the outward K+ current in the absence of added cAMP. Our results indicate that cAMP modulates K+ channel activity in mesophyll cells and suggest that this modulation occurs through a cAMP-regulated protein kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.