ArticleJournal of virology1995
Expression of cyclin D2 in Epstein-Barr virus-positive Burkitt's lymphoma cell lines is related to methylation status of the gene.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2.Journal of virology · 2018Article
- Article
- A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency.Journal of virology · 2015Article
- Article
- Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer.Journal of molecular medicine (Berlin, Germany) · 2006Article
- Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.Oncogene · 2006Article
- Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties.Journal of virology · 2004Article
- Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal.Molecular psychiatry · 2004Article
- Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer.British journal of cancer · 2003Article
- Identification of the in vivo role of a viral bcl-2.The Journal of experimental medicine · 2002Article
- Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency.Journal of virology · 2000Article
- The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.Journal of virology · 2000Article
- Signaling activities of gammaherpesvirus membrane proteins.Journal of virology · 2000Review
- Aberrant DNA methylation of cyclin D2 and p27 genes in rodent pituitary tumor cell lines correlates with specific gene expression.Endocrine pathology · 2000Article
- Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1-infected cells.Journal of virology · 1999Article
- The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes.Journal of virology · 1999Article
- Complete sequence and genomic analysis of murine gammaherpesvirus 68.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cyclin D2 gene is not expressed in resting primary B lymphocytes or in group I Burkitt's lymphoma (BL) cell lines that retain the characteristics of authentic BL cells. Expression of cyclin D2 is induced in primary B lymphocytes following infection with Epstein-Barr virus (EBV) or transfection of the EBV genes EBNA-LP and EBNA-2. However, attempts to induce cyclin D2 expression in BL cell lines by the enforced expression of EBV genes were unsuccessful. Since the demethylation agent 5-azacytidine has been shown to modulate viral gene expression in BL cells, we explored the possibility that methylation plays a significant role in the control of cyclin D2 expression. We show that 5-azacytidine treatment of the Mutu CI 179 BL cell line led to expression of cyclin D2 RNA and that expression correlated with differences in the methylation status of a CCGG restriction enzyme site near the transcription initiation region of the cyclin D2 gene. Thus, methylation appears to play a direct role in the regulation of the cyclin D2 locus in BL.
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