Evidence map›Paper›PMID 7529317›Full record

ArticleJournal of medical genetics1994

An extra band within the human 9qh+ region that behaves like the surrounding constitutive heterochromatin.

J L Fernández, S Pereira, A Campos, J Gosálvez, V Goyanes

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of medical genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J L FernándezCentro Oncológico de Galicia, Laboratorio de Genética, La Coruña, Spain.
S Pereira
A Campos
J Gosálvez
V Goyanes
Centro Oncológico de Galicia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An extra variant G band in a human 9qh+ region was analysed in normally condensed and 5-azacytidine undercondensed chromosomes. Fluorescence in situ hybridisation showed that specific, classical, alphoid and beta satellite DNA was not present. Nevertheless, this extra band behaves like the surrounding heterochromatin because (1) its chromatin fibres showed condensation inhibition after 5-azacytidine treatment, as confirmed by electron microscopy, and (2) it was not affected by in situ digestion with the restriction endonucleases AluI and Sau3A. These results suggest that this variant band may correspond to euchromatin that has become inactivated by a position effect.

Indexed as

Chromosome Aberrations5-MethylcytosineAdultAzacitidineChromosome BandingChromosomes, HumanChromosomes, Human, Pair 9CytosineHeterochromatinHumansIn Situ Hybridization, FluorescenceLymphocytesMaleMethylationMicroscopy, Electron5-MethylcytosineAzacitidineCytosineHeterochromatin

Identifiers

PMID7529317
PMCPMC1050026
OpenAlexW1986458990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.