ArticleExperimental brain research1994
Subthreshold rectification in neostriatal spiny projection neurons.
Article in Experimental brain research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 30 citations in OpenAlex.
- Ionic and morphological contributions to the variable gain of membrane responses in layer 2/3 pyramidal neurons of mouse primary visual cortex.Journal of neurophysiology · 2022Article
- Dopaminergic modulation of spiny neurons in the turtle striatum.Cellular and molecular neurobiology · 2010Article
- Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents.The Journal of physiology · 2009Article
- Turning off cortical ensembles stops striatal Up states and elicits phase perturbations in cortical and striatal slow oscillations in rat in vivo.The Journal of physiology · 2006Article
- Spontaneous voltage oscillations in striatal projection neurons in a rat corticostriatal slice.The Journal of physiology · 2003Article
- Dopaminergic modulation of axon collaterals interconnecting spiny neurons of the rat striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Cholinergic modulation of neostriatal output: a functional antagonism between different types of muscarinic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Anesthetics eliminate somatosensory-evoked discharges of neurons in the somatotopically organized sensorimotor striatum of the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Up and down states in striatal medium spiny neurons simultaneously recorded with spontaneous activity in fast-spiking interneurons studied in cortex-striatum-substantia nigra organotypic cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Inhibitory action of dopamine involves a subthreshold Cs(+)-sensitive conductance in neostriatal neurons.Experimental brain research · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular recordings from slice preparations were used to assess the subthreshold electrophysiological behavior of rat neostriatal projection neurons. Both current steps and ramp currents were used to estimate the current-voltage relationship (I-V plot). Inward rectification in the subthreshold range was a characteristic of most neurons. The amount of rectification varied greatly, and it was complex: membrane voltage trajectories in response to ramps were made up by almost piece-wise changes in the rate of voltage rise, suggesting that multiple conductances contribute to the subthreshold range. Inward current blockers such as tetrodotoxin (TTX) or Cd2+ decreased inward rectification, whereas outward current blockers such as tetraethylammonium (TEA) or 4-aminopyridine (4-AP) increased inward rectification. However, most inward rectification was due to TEA- and Cs(+)-sensitive conductances and not to TTX- or Cd(2+)-sensitive conductances. Cs(+)-sensitive conductances predominated at more negative membrane potentials, whereas 4-AP-sensitive conductances predominated at just +/- 10 mV below the firing threshold. In spite of a very slow activation, there was evidence for transient outward currents modulating the response, i.e., 4-AP-sensitivity, and voltage-sensitivity for firing frequency and threshold. TEA-sensitive conductances also contributed toward fixing the firing threshold. These results imply the contribution of various ion conductances on the shaping of the characteristic physiological firing recorded in vivo. Modulation of these responses by transmitters or peptides may help to understand neural processing in the neostriatum.
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