ArticleThe American journal of pathology1994
Protein and mRNA expression of simple epithelial keratins in normal, dysplastic, and malignant oral epithelia.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Development of 3D gingival in vitro models using primary gingival cells.In vitro cellular & developmental biology. Animal · 2024Article
- Unraveling the Keratin Expression in Oral Leukoplakia: A Scoping Review.International journal of molecular sciences · 2024Article
- Utility of Keratins as Biomarkers for Human Oral Precancer and Cancer.Life (Basel, Switzerland) · 2022Review
- Oral Mucosal Epithelial Cells.Frontiers in immunology · 2019Review
- The TF-miRNA Coregulation Network in Oral Lichen Planus.BioMed research international · 2015Article
- HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes.Experimental dermatology · 2007Article
- Cytokeratin expression in human fetal tongue and buccal mucosa.Journal of biosciences · 2000Article
- Regulation of keratin and integrin gene expression in cancer and drug resistance.Cytotechnology · 1998Article
- Interspecies variations in oral epithelial cytokeratin expression.Journal of anatomy · 1998Article
- Pattern of expression of intermediate cytokeratin filaments in the thyroid gland: an immunohistochemical study of simple and stratified epithelial-type cytokeratins.Virchows Archiv : an international journal of pathology · 1997Article
- Per[cyst]ent growth: the odontogenic keratocyst 40 years on.Annals of the Royal College of Surgeons of England · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Simple epithelial keratins K7, K8, and K18 are present in no more than trace amounts in normal stratified squamous epithelial but have been reported in squamous cell carcinomas. With the aim of determining the level at which keratin synthesis is regulated in vivo, we have compared the expression of mRNA by in situ hybridization and protein by immunohistochemistry for K7, K8, and K18 in a series of normal, dysplastic, and malignant oral epithelia. In normal epithelia mRNAs for K7, K8, and K18 were present in basal and lower spinous cells but adjacent sections were generally negative for the respective proteins. In severe dysplasia there was irregular suprabasal extension of K8 and K18 mRNAs in all cases and their proteins were expressed in more than half of the cases. The carcinomas expressed K8 and K18 mRNAs homogeneously and were strongly reactive for these keratin proteins but K7 expression appeared reduced in malignancy. These results are consistent with the post-transcriptional regulation of K7, K8, and K18 expression in normal epithelia and the presence of their proteins in dysplastic and malignant epithelia suggests the release of these epithelial cells from a post-transcriptional block on K8 and K18 translation. Alternatively, rapid degradation of K8 and K18 protein might be occurring in normal epithelia but be suppressed in dysplasia and malignancy.
Indexed as
Identifiers
7527618PMC1887511W40428587What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.