ArticleProceedings of the National Academy of Sciences of the United States of America1994
Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 180 citations in OpenAlex.
- Rad-mediated inhibition of CaThe Journal of physiology · 2024Article
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- A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle.bioRxiv : the preprint server for biology · 2024Article
- Halofuginone, a promising drug for treatment of pulmonary hypertension.British journal of pharmacology · 2021Article
- Vascular Kv7 channels control intracellular CaCell calcium · 2020Article
- CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With MediterraneanHypertension (Dallas, Tex. : 1979) · 2020Article
- Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias.The Journal of innovations in cardiac rhythm management · 2019Review
- Control of Motility in the Internal Anal Sphincter.Journal of neurogastroenterology and motility · 2019Article
- Dehydroepiandrosterone inhibits IAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Comparison of inhibitory neuromuscular transmission in the Cynomolgus monkey IAS and rectum: special emphasis on differences in purinergic transmission.The Journal of physiology · 2018Article
- Contribution of L-type CaHypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Voltage effects on muscarinic acetylcholine receptor-mediated contractions of airway smooth muscle.Physiological reports · 2018Article
- Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles.PloS one · 2018Article
- Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.British journal of pharmacology · 2017Article
- Lower Affinity of Isradipine for L-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.The Journal of general physiology · 2017Article
- Regulation of Coronary Blood Flow.Comprehensive Physiology · 2017Review
- Sustained Contraction in Vascular Smooth Muscle by Activation of L-type CaFrontiers in pharmacology · 2016Article
- Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.PloS one · 2015Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Action potentials activate voltage-dependent calcium channels and attendant increases in cytosolic calcium concentration ([Ca2+]i) in many excitable cells. The role of these channels in the regulation of [Ca2+]i in nonspiking cells that do not depolarize to membrane potentials sufficient to activate a substantial fraction of the available current is less clear. Measurements of the peak activation and steady-state inactivation of L-type calcium currents have predicted the existence of a noninactivating current window over a voltage range where channel inactivation is incomplete. The degree to which such small currents might regulate [Ca2+]i, however, has not been established. Here we demonstrate a "calcium window" in nondialyzed, quiescent smooth muscle cells over a small voltage range near the resting membrane potential. Sustained depolarizations in this voltage range, but not to more positive potentials, resulted in sustained rises in calcium, despite the fact that macroscopic inward currents were < 2 pA. The calcium window corresponded well with the predicted window current determined under the same conditions; the peak of the calcium window occurred at -30 mV, with steady-state rises in [Ca2+]i in some cells at -50 mV. Steady-state rises in [Ca2+]i following depolarization were completely blocked by nisoldipine and were augmented and shifted to more negative potentials by BAY K8644. Voltage-dependent calcium channels thus regulate steady-state calcium levels in nonspiking cells over a voltage range where macroscopic currents are only barely detectable. This voltage range is bounded at negative potentials by calcium channel activation and at more positive potentials by channel inactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.