ArticleThe Journal of clinical investigation1994
Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway.British journal of pharmacology · 2000Trial
- Itaconate as a key regulator of respiratory disease.Clinical and experimental immunology · 2024Review
- The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease.Frontiers in medicine · 2018Review
- Myeloid Cells in Asthma.Microbiology spectrum · 2017Review
- The immunology of asthma.Nature immunology · 2015Article
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Stimulatory effect of CO2 on vagal bronchopulmonary C-fiber afferents during airway inflammation.Journal of applied physiology (Bethesda, Md. : 1985) · 2005Article
- Hypersensitivity of pulmonary C fibre afferents induced by cationic proteins in the rat.The Journal of physiology · 2001Article
- A comparison of allergen and polycation induced cutaneous responses in the rabbit.British journal of pharmacology · 2001Article
- Eosinophil granule-derived major basic protein induces IL-8 expression in human intestinal myofibroblasts.Clinical and experimental immunology · 2000Article
- Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea-pigs.British journal of pharmacology · 1999Article
- Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease.Mediators of inflammation · 1999Review
- Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness.The Journal of experimental medicine · 1997Article
- Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody.The Journal of experimental medicine · 1996Article
- In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs.The Journal of clinical investigation · 1996Article
- Th2 cells and cytokine networks in allergic inflammation of the lung.Mediators of inflammation · 1995Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We have previously reported that human eosinophil granule major basic protein and synthetic cationic proteins such as poly-L-arginine and poly-L-lysine, can increase airway responsiveness in vivo. In the present study, we have investigated whether activation of sensory C-fibers is important in this phenomenon. Dose-response curves to methacholine were constructed before and 1 h after intratracheal instillation of poly-L-lysine in anaesthetized spontaneously breathing rats, and the concentration of methacholine required to induce a doubling in total lung resistance was calculated. Poly-L-lysine induced a fivefold increase in airway responsiveness, which was inhibited by neonatal capsaicin treatment and potentiated by phosphoramidon (100 micrograms/ml). Furthermore, pretreatment with either CP, 96-345, or RP-67580 two selective NK-1 receptor antagonists inhibited poly-L-lysine-induced airway hyperresponsiveness and plasma protein extravasation. In vitro, cationic proteins stimulated the release of calcitonin gene-related peptide-like immunoreactivity from perfused slices of the main bronchi. Our results demonstrate that cationic proteins can activate sensory C-fibers in the airways, an effect which is important in the subsequent development of airway hyperresponsiveness and plasma protein extravasation. Cationic proteins may therefore function as a link between inflammatory cell accumulation and sensory nerve activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.