ArticleProceedings of the National Academy of Sciences of the United States of America1994
A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 99 citations in OpenAlex.
- Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke.Brain research · 2015Review
- Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity.Translational psychiatry · 2012Article
- Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.Trends in neurosciences · 2009Review
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.Nature reviews. Neuroscience · 2008Review
- The myelin-pathogenesis puzzle in schizophrenia: a literature review.Molecular psychiatry · 2008Review
- Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage.Neonatology · 2008Review
- The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.Neuron · 2007Article
- ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.Journal of molecular neuroscience : MN · 2006Article
- The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.Journal of molecular neuroscience : MN · 2005Article
- Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia.Molecular psychiatry · 2004Article
- The role of ErbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation.Cellular and molecular neurobiology · 2001Article
- Multiple system atrophy: cellular and molecular pathology.Molecular pathology : MP · 2001Review
- The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes.The Journal of cell biology · 2001Article
- Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Regulation of neuregulin expression in the injured rat brain and cultured astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Failure of spinal cord oligodendrocyte development in mice lacking neuregulin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ARIA acetylcholine receptor-inducing activity protein, is a member of a family of ligands that includes the Neu differentiation factor, heregulin, and glial growth factor. These ligands all act through one or more receptor tyrosine kinases of approximately 185 kDa. In some conditions these ligands promote proliferation, whereas in others they induce differentiation. ARIA was originally isolated from chick brain on the basis of its ability to induce synthesis of nicotinic acetylcholine receptors in skeletal muscle. In this paper we show that ARIA is expressed in the subventricular zone of the rat brain and that it enhances the development of oligodendrocytes from bipotential (O2A) glial progenitor cells. We have also found that ARIA induces tyrosine phosphorylation of a 185-kDa protein in O2A progenitor cells. ARIA does not increase bromodeoxyuridine incorporation by oligodendrocytes but is mitogenic when added to Schwann cells in vitro. Thus, ARIA accelerates the formation of oligodendrocytes in vitro and is expressed where it could exercise the same influence in vivo.
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