ArticleProceedings of the National Academy of Sciences of the United States of America1994
Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 200 citations in OpenAlex.
- Murine Model of Radiation Dermatitis with Experimental Wound and Effects of Genistein.International journal of molecular sciences · 2026Article
- Apoptosis of Eosinophil Granulocytes.Biology · 2020Review
- Article
- Review
- Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway.Stem cell research & therapy · 2013Article
- Peculiarities of cell death mechanisms in neutrophils.Cell death and differentiation · 2011Review
- Involvement of Src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite Entamoeba histolytica.The Korean journal of parasitology · 2010Article
- Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality.Radiation research · 2010Article
- Radioprotectors and mitigators of radiation-induced normal tissue injury.The oncologist · 2010Review
- Lipoxin A4 counterregulates GM-CSF signaling in eosinophilic granulocytes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Anaplasma phagocytophilum delay of neutrophil apoptosis through the p38 mitogen-activated protein kinase signal pathway.Infection and immunity · 2005Article
- Mycobacterium tuberculosis triggers apoptosis in peripheral neutrophils involving toll-like receptor 2 and p38 mitogen protein kinase in tuberculosis patients.Infection and immunity · 2004Article
- Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils.The Journal of experimental medicine · 2004Article
- Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration.Thorax · 2004Article
- Increased Protein Tyrosine Phosphorylation in Apoptotic Neural Cell Death Due to Microtubule Perturbations.Neurotoxicity research · 2000Article
- Involvement of protein tyrosine phosphatases in activation of the trimeric G protein Gq/11.Oncogene · 1999Article
- Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.British journal of pharmacology · 1999Article
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- Article
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Authors and funding
4 authors.
Funding
Abstract
Early signaling events that control the process of programmed cell death are largely unknown. Tyrosine phosphorylation plays a major role in transmembrane signal transduction through most cell surface receptors. Granulocyte/macrophage colony-stimulating factor (GM-CSF), a cytokine released by activated T cells, has been shown to increase tyrosine phosphorylation in several cells and to inhibit granulocyte cell death in vitro. In this study, we demonstrate that the effect of GM-CSF on granulocyte cell death can be blocked by the tyrosine kinase inhibitor genistein, suggesting that increases in tyrosine phosphorylation are essential to inhibit cell death. To analyze the role of tyrosine phosphorylation for the regulation of granulocyte cell death more precisely, we increased levels of tyrosine phosphorylation using the protein-tyrosine phosphatase inhibitor phenylarsine oxide (PAO). Similar to GM-CSF, treatment of the cells with PAO was followed by high increases in tyrosine phosphorylation and inhibition of programmed cell death in human eosinophils and neutrophils. Strikingly, at low concentrations of the inhibitor and low induction of tyrosine phosphorylation, acceleration of apoptosis was observed. Genistein and herbimycin A reversed the effects of PAO on tyrosine phosphorylation and granulocyte apoptosis. These results suggest that programmed eosinophil and neutrophil death is regulated by early events of signal transduction pathways such as tyrosine phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.