ArticlePflugers Archiv : European journal of physiology1994
Spontaneous transient inward currents and rhythmicity in canine and guinea-pig tracheal smooth muscle cells.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Pulmonary circulation · 2015Review
- Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by β-agonists.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness.American journal of respiratory and critical care medicine · 2013Article
- Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2013Article
- Chloride in airway smooth muscle: the ignored anion no longer?American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes.The Journal of general physiology · 2011Article
- Ca2+ sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle.The Journal of biological chemistry · 2010Article
- Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells.British journal of pharmacology · 2009Article
- Membrane current oscillations in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2008Article
- Regional differences in nitrergic innervation of the smooth muscle of murine lower oesophageal sphincter.British journal of pharmacology · 2008Article
- Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.The European respiratory journal · 2007Review
- Ca2+ signalling in urethral interstitial cells of Cajal.The Journal of physiology · 2006Review
- Diversity of Cl(-) channels.Cellular and molecular life sciences : CMLS · 2006Review
- Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes.Pflugers Archiv : European journal of physiology · 2004Article
- Role of sarcoplasmic reticulum in control of membrane potential and nitrergic response in opossum lower esophageal sphincter.British journal of pharmacology · 2003Article
- Stretch-induced calcium release in smooth muscle.The Journal of general physiology · 2002Article
- Mechanism of generation of spontaneous miniature outward currents (SMOCs) in retinal amacrine cells.The Journal of general physiology · 2002Article
- Nitric oxide contracts longitudinal smooth muscle of opossum oesophagus via excitation-contraction coupling.The Journal of physiology · 2001Article
- Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase.The Journal of physiology · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous transient inward currents (STICs) were recorded in canine and guinea-pig tracheal myocytes held at negative membrane potentials. STICs were Cl- selective since their reversal potential was dependent on the Cl- gradient and they were blocked by the Cl- channel blocker niflumic acid. STICs were insensitive to Cs+, charybdotoxin, and nifedipine. Ca(2+)-activated K+ currents often preceded STICs, suggesting that the STICs are Ca2+ dependent. In support of this suggestion, we found the Cl- currents were: (1) abolished by depleting intracellular Ca2+ stores using caffeine, acetylcholine, histamine, or substance P; (2) enhanced by increasing external concentrations of Ca2+; (3) evoked by voltage-dependent Ca2+ influx. The channels responsible for this Cl- current are of small unitary conductance (< 20 pS). Decay of the STICs was described by a single exponential with a time constant of 94 +/- 9 ms at -70 mV; the time constant increased considerably at more positive potentials. Using Ca(2+)-dependent Cl- currents and contractions as indices of internal levels of Ca2+, we found that isolated tracheal cells are capable of exhibiting rhythmic behaviour: bursts of currents and contractions with a periodicity of less than 0.1 Hz and which continued for more than 20 min. These rhythmic events were recorded at negative membrane potentials, suggesting that cyclical release of internally sequestered Ca2+ is responsible. We conclude that spontaneous release of Ca2+ from intracellular stores in tracheal muscle cells leads to transient currents in some cases accompanied by rhythmic contractions. Our studies provide evidence for a cellular mechanism that could underly myogenic oscillations of membrane potential in smooth muscle.
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