ReviewJournal of neuro-oncology1994
Tumor invasion, proteolysis, and angiogenesis.
Review in Journal of neuro-oncology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 69 citations in OpenAlex.
- Expression of a urokinase-type plasminogen activator during tumor growth leads to angiogenesis via galanin activation in tumor-bearing mice.FEBS open bio · 2017Article
- Modelling Tumor-induced Angiogenesis: Combination of Stochastic Sprout Spacing and Sprout Progression.Journal of biomedical physics & engineering · 2017Article
- Article
- Front instabilities and invasiveness of simulated avascular tumors.Bulletin of mathematical biology · 2009Article
- The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis.BMC cancer · 2006Article
- Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.Japanese journal of cancer research : Gann · 2002Article
- Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer.British journal of cancer · 1999Article
- Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors.Gene therapy · 1999Article
- Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis.Clinical & experimental metastasis · 1998Article
- Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage.British journal of cancer · 1997Article
- Management of primary malignant brain tumours.Journal of neurology, neurosurgery, and psychiatry · 1996Review
- Morphologic, immunologic, biochemical, and cytogenetic characteristics of the human glioblastoma-derived cell line, SNB-19.In vitro cellular & developmental biology. Animal · 1995Article
- Interactions of glioma cells and extracellular matrix.Journal of neuro-oncology · 1995Review
- Degradation of collagen type IV by C6 astrocytoma cells.Journal of neuro-oncology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, some of the current literature on the regulation of proteolysis and angiogenesis during tumor invasion is discussed. Due to the critical location of brain tumors, an understanding of tumor cell interactions with the local environment is particularly relevant. Tissue breakdown during tumor invasion is associated with proteolytic activity, mediated by tumor cells, and surrounding host cells. This review covers two classes of proteinases and inhibitors that have commonly been associated with tumor invasion i.e., plasminogen activator (PA)/plasmin and matrix metalloproteinases (MMP) with special emphasis on the MMP inhibitors, TIMP-1 and TIMP-2. At different steps of the metastatic process, tumor cells interact with endothelial cells. Tumor cells also stimulate the formation of new vessels through the expression of specific angiogenic molecules. At least eight angiogenic molecules have been purified, sequenced and cloned, four of which are discussed here. Regulation of angiogenic activity has been the focus of intense studies recently, and a wide range of synthetic and natural angiogenesis inhibitors have been discovered. Targeting of angiogenic molecules and tumor vasculature may prove useful in future cancer therapeutic strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.