ArticleThe Journal of experimental medicine1994
CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 116 citations in OpenAlex.
- Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy.Results and problems in cell differentiation · 2026Review
- Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2.Experimental & molecular medicine · 2024Review
- CD58 Immunobiology at a Glance.Frontiers in immunology · 2021Review
- CD2 Immunobiology.Frontiers in immunology · 2020Review
- The nature of activatory and tolerogenic dendritic cell-derived signal II.Frontiers in immunology · 2013Article
- Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.The Journal of experimental medicine · 2012Article
- A feline CD2 homologue interacts with human red blood cells.Immunology · 2002Article
- Human alloantigen-specific anergic cells induced by a combination of CTLA4-Ig and CsA maintain anti-leukemia and anti-viral cytotoxic responses.Bone marrow transplantation · 2001Article
- Enhancement of cALL immunogenicity by co-culture with a CD154 expressing 293 cell line.Clinical and experimental immunology · 2001Article
- T cell signal transduction and the role of CD7 in costimulation.Immunologic research · 2001Review
- Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.The EMBO journal · 1999Article
- Diminished IL-2 responses and alteration of CD2 expression on CD8+ T cells are associated with a lack of cytotoxic T cell responses during Theileria annulata infection.Clinical and experimental immunology · 1999Article
- Regulation of integrin function by T cell activation: points of convergence and divergence.Immunologic research · 1999Review
- A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.The EMBO journal · 1998Article
- Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The counterreceptor binding site of human CD2 exhibits an extended surface patch with multiple conformations fluctuating with millisecond to microsecond motions.Protein science : a publication of the Protein Society · 1997Article
- Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding.Molecular and cellular biology · 1997Article
- Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis.The Journal of clinical investigation · 1996Article
- Anergic TH1 clones specific for hepatitis B virus (HBV) core peptides are inhibitory to other HBV core-specific CD4+ T cells in vitro.Journal of virology · 1996Article
- Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Induction and maintenance of a state of T cell unresponsiveness to specific alloantigen would have significant implications for human organ transplantation. Using human histocompatibility leukocyte antigen DR7-specific helper T cell clones, we demonstrate that blockade of the B7 family of costimulatory molecules is sufficient to induce alloantigen-specific T cell clonal anergy. Anergized cells do not respond to alloantigen and a variety of costimulatory molecules, including B7-1, B7-2, intercellular adhesion molecule-1 (ICAM-1), and lymphocyte function-associated molecule (LFA)-3. However, after culture in exogenous interleukin (IL)-2 for at least 7 d, anergized cells can respond to alloantigen in the presence of LFA-3. LFA-3 costimulation subsequently restores responsiveness to alloantigen in the presence of previously insufficient costimulatory signals. Expression of CD2R epitope is downregulated on anergic cells and is restored after 7 d of IL-2 culture. The loss of the CD2R is temporally associated with the inability of anergized cells to respond to LFA-3. These results suggest that in addition to blockade of B7 family members, inhibition of CD2 and, potentially, other costimulatory pathways that might reverse anergy will be necessary to maintain prolonged alloantigen-specific tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.