ArticleThe Journal of cell biology1994
E1a induces the expression of epithelial characteristics.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
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- Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.Molecular immunology · 2019Article
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- A Bottleneck in Understanding Metastatic Cancer Stem Cell of Peritoneal Seeding from Gastric Cancer: A Null Result in Brief.Journal of Cancer · 2017Article
- Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis.Scientific reports · 2016Article
- HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas.Oncotarget · 2016Article
- Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Opposing oncogenic activities of small DNA tumor virus transforming proteins.Trends in microbiology · 2011Review
- Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation.Translational oncology · 2009Article
- Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara.Virus research · 2009Article
- Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.Cancer biology & therapy · 2009Article
- Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.Cancer biology & therapy · 2009Article
- The transcriptional corepressor CtBP: a foe of multiple tumor suppressors.Cancer research · 2009Review
- BAR the door: cancer suppression by amphiphysin-like genes.Biochimica et biophysica acta · 2009Review
- Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.Oncogene · 2006Article
- Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.Oncogene · 2006Article
- Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells.American journal of human genetics · 2005Article
- Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cells closely resembling epithelia constitute the first specific cell type in a mammalian embryo. Many other cell types emerge via epithelial-mesenchymal differentiation. The transcription factors and signal transduction pathways involved in this differentiation are being elucidated. I have previously reported (Frisch, 1991) that adenovirus E1a is a tumor suppressor gene in certain human cell lines. In the present report, I demonstrate that E1a expression caused diverse human tumor cells (rhabdomyosarcoma, fibrosarcoma, melanoma, osteosarcoma) and fibroblasts to assume at least two of the following epithelial characteristics: (a) epithelioid morphology; (b) epithelial-type intercellular adhesion proteins localized to newly formed junctional complexes; (c) keratin-containing intermediate filaments; and (d) down-regulation of non-epithelial genes. E1a thus appeared to partially convert diverse human tumor cells into an epithelial phenotype. This provides a new system for molecular analysis of epithelial-mesenchymal interconversions. This effect may also contribute to E1a's tumor suppression activity, possibly through sensitization to anoikis (Frisch, S.M., and H. Francis, 1994. J. Cell Biol. 124:619-626).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.