ArticleJournal of cancer research and clinical oncology1994
Pineal parenchymal tumors: cell differentiation and prognosis.
Article in Journal of cancer research and clinical oncology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.Neurosurgical review · 2022Pooled it
- Understanding and Managing Pineal Parenchymal Tumors of Intermediate Differentiation: An In-Depth Exploration from Pathology to Adjuvant Therapies.Journal of clinical medicine · 2024Review
- Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.Neuro-oncology · 2017Article
- Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.Cell stress & chaperones · 2005Review
- Pathology of pineal region tumors.Journal of neuro-oncology · 2001Review
- Cytogenetic and ultrastructural study of a pineocytoma case report.Journal of neuro-oncology · 2000Article
- Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases.Brain pathology (Zurich, Switzerland) · 2000Review
- Pineal ganglioneuroblastoma in an adult.Journal of neuro-oncology · 1999Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eleven pineal parenchymal tumors were studied using various antibodies specific to the central nervous system and cell-proliferation-related antigen MIB-1 in order to examine the divergent types of cell differentiation and also evaluate prognosis. Electron microscopy was also performed. All tumors were immunohistochemically positive to chromogranin A and alpha B crystallin, and were also highly positive to retinal S protein. Pineocytoma cells contained microtubules, intermediate filaments, glial bundles, clear-centered vesicles and synaptic apparati. Pineoblastoma cells also had microtubules and neurofilaments, but glial filaments and definite synapses were not identifiable. Pineal parenchymal tumors were considered to be of pinealocyte origin, and there was a continuous spectrum of divergent cell differentiation between pineocytoma and pineoblastoma cells. The MIB-1 labeling index correlated well with histological malignancy, neuronal differentiation evaluated immunohistochemically by both neurofilament protein and synaptophysin, and cases with seeding potentials. Although histopathological features of neuronal development were, until recently, seen as the hallmark of benign prognosis in pineal parenchymal tumors, they are now thought to be only one of the pieces of evidence that may be used for purposes of prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.