ArticleThe EMBO journal1994
Homing of a group II intron in yeast mitochondrial DNA is accompanied by unidirectional co-conversion of upstream-located markers.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Comparative mitogenomic analysis ofFrontiers in physiology · 2024Article
- Targetron-Assisted Delivery of Exogenous DNA Sequences intoACS synthetic biology · 2021Article
- Origin and Spread of Spliceosomal Introns: Insights from the Fungal Clade Zymoseptoria.Genome biology and evolution · 2017Article
- Article
- Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution.Microbiology spectrum · 2015Review
- The mitochondrial LSU rRNA group II intron of Ustilago maydis encodes an active homing endonuclease likely involved in intron mobility.PloS one · 2012Article
- Recurrent insertion of 5'-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs.RNA (New York, N.Y.) · 2011Article
- Evolutionary dynamics of the mS952 intron: a novel mitochondrial group II intron encoding a LAGLIDADG homing endonuclease gene.Journal of molecular evolution · 2011Article
- The Rieske FeS protein encoded and synthesized within mitochondria complements a deficiency in the nuclear gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Compilation and analysis of group II intron insertions in bacterial genomes: evidence for retroelement behavior.Nucleic acids research · 2002Article
- Mutually exclusive distribution of IS1548 and GBSi1, an active group II intron identified in human isolates of group B streptococci.Journal of bacteriology · 2001Article
- Multiple homing pathways used by yeast mitochondrial group II introns.Molecular and cellular biology · 2000Article
- Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences.Genes & development · 2000Article
- Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA.The EMBO journal · 1997Article
- A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron.Genes & development · 1997Article
- Homing of a group II intron from Lactococcus lactis subsp. lactis ML3.Journal of bacteriology · 1997Article
- Replacement of two non-adjacent amino acids in the S.cerevisiae bi2 intron-encoded RNA maturase is sufficient to gain a homing-endonuclease activity.The EMBO journal · 1996Article
- The S. cerevisiae nuclear gene SUV3 encoding a putative RNA helicase is necessary for the stability of mitochondrial transcripts containing multiple introns.Current genetics · 1995Article
- Prokaryotic introns and inteins: a panoply of form and function.Journal of bacteriology · 1995Review
- Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements.Molecular and cellular biology · 1995Article
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3 authors.
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Abstract
Group II introns ai1 and ai2 of the Saccharomyces cerevisiae mitochondrial COXI gene encode proteins having a dual function (maturase and reverse transcriptase) and are mobile genetic elements. By construction of adequate donor genomes, we demonstrate that each of them is self-sufficient and practises homing in the absence of homing-type endonucleases encoded by either group I introns or the ENS2 gene. Each of the S. cerevisiae group II self-mobile introns was tested for its ability to invade mitochondrial DNA (mtDNA) from two related Saccharomyces species. Surprisingly, only ai2 was observed to integrate into both genomes. The non-mobility of ai1 was clearly correlated with some polymorphic changes occurring in sequences flanking its insertion sites in the recipient mtDNAs. Importantly, studies of the behaviour of these introns in interspecific crosses demonstrate that flanking marker co-conversion accompanying group II intron homing is unidirectional and efficient only in the 3' to 5' direction towards the upstream exon. Thus, the polar co-conversion and dependence of the splicing proficiency of the intron reported previously by us are hallmarks of group II intron homing, which significantly distinguish it from the strictly DNA-based group I intron homing and strictly RNA-based group II intron transposition.
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