ArticleThe American journal of pathology1994
Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.Molecular and cellular biology · 2011Article
- The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.Blood · 2011Article
- A novel isoform of microphthalmia-associated transcription factor inhibits IL-8 gene expression in human cervical stromal cells.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.Journal of leukocyte biology · 2008Article
- Development of mast cells: analysis with mutant mice.International journal of hematology · 2007Review
- Microphthalmia transcription factor isoforms in mast cells and the heart.Molecular and cellular biology · 2007Article
- Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Transcription factor MITF regulates cardiac growth and hypertrophy.The Journal of clinical investigation · 2006Article
- Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes.Molecular and cellular biology · 2004Article
- Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3.Molecular and cellular biology · 2003Article
- Synergy of PEBP2/CBF with mi transcription factor (MITF) for transactivation of mouse mast cell protease 6 gene.Oncogene · 1999Article
- Alteration of protease expression phenotype of mouse peritoneal mast cells by changing the microenvironment as demonstrated by in situ hybridization histochemistry.The American journal of pathology · 1998Article
- Involvement of transcription factor encoded by the mouse mi locus (MITF) in apoptosis of cultured mast cells induced by removal of interleukin-3.The American journal of pathology · 1997Article
- Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization.The American journal of pathology · 1997Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mi locus of mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called mi factor). In addition to microphthalmus, osteopetrosis, and lack of melanocytes, mice of mi/mi genotype are deficient in mast cells. Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit. However, it remained to be examined whether the c-kit expression was also deficient in tissues of mi/mi mice. In the present study, we examined the c-kit expression by mi/mi skin mast cells using in situ hybridization and immunohistochemistry. Moreover, we examined the c-kit expression by various cells other than mast cells in tissues of mi/mi mice. We found that the c-kit expression was deficient in mast cells but not in erythroid precursors, testicular germ cells, and neurons of mi/mi mice. This suggested that the regulation of the c-kit transcription by the mi factor was dependent on cell types. Mice of mi/mi genotype appeared to be a useful model to analyze the function of transcription factors in the whole-animal level.
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Identifiers
7524330PMC1887326W1468755370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.