ArticleProceedings of the National Academy of Sciences of the United States of America1994
Disproportionate growth in mice with Igf-2 transgenes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 105 citations in OpenAlex.
- Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion.PLoS genetics · 2025Article
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Insulin-like growth factors: Ligands, binding proteins, and receptors.Molecular metabolism · 2021Review
- Epigenetic regulation of the Igf2/H19 gene cluster.Cell proliferation · 2014Review
- Targeting insulin and insulin-like growth factor signaling in breast cancer.Journal of mammary gland biology and neoplasia · 2012Review
- Insulin-like growth factors in the gastrointestinal tract and liver.Endocrinology and metabolism clinics of North America · 2012Review
- Growth hormone, the insulin-like growth factor axis, insulin and cancer risk.Nature reviews. Endocrinology · 2011Review
- Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.The EMBO journal · 2008Article
- The growth hormone-insulin-like growth factor-I axis in chronic kidney disease.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2008Review
- A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.BMC developmental biology · 2007Article
- The effect of parental imprinting on the INS-IGF2 locus of Korean type I diabetic patients.The Korean journal of internal medicine · 2001Article
- Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Insulin-like growth factors in central nervous system tumors.Journal of neuro-oncology · 1997Review
- Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome.Journal of medical genetics · 1997Article
- Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice.Transgenic research · 1997Article
- IGF-II dependent autocrine growth in cell lines derived from renal tumours of childhood.Clinical molecular pathology · 1995Article
- Insulin-like growth factors: the unrecognised oncogenes.British journal of cancer · 1995Article
- Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)British journal of cancer · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injection transgenesis was used to study the long-term effects of excess insulin-like growth factor II on mouse growth and differentiation. By using a construct in which the coding region of the mouse insulin like growth factor II gene (Igf-2) was placed under the control of a keratin gene promoter, four transgenic lines were established, all of which displayed overgrowth of the skin as judged by wrinkling. In addition to high levels of expression in the skin, transgene transcripts were also present in the alimentary canal and uterus. At most of the sites of transgene expression the cell number (DNA content) was greatly increased, indicating a local action of the excess insulin-like growth factor II on cell multiplication. Adult total live weight was slightly increased and there was no macroscopic evidence of tumor formation. The characteristics of these transgenic mice indicate distinct local and systemic actions for insulin-like growth factor II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.