ArticleThe Journal of physiology1994
Functional role of bicarbonate in propionate transport across guinea-pig isolated caecum and proximal colon.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 43 citations in OpenAlex.
- Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis.Experimental & molecular medicine · 2021Review
- Article
- pH gradients and a micro-pore filter at the luminal surface affect fluxes of propionic acid across guinea pig large intestine.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
- Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum.Pflugers Archiv : European journal of physiology · 2007Article
- Low carbon dioxide permeability of the apical epithelial membrane of guinea-pig colon.The Journal of physiology · 2005Article
- Maintenance and regulation of the pH microclimate at the luminal surface of the distal colon of guinea-pig.The Journal of physiology · 1999Article
- The characterization of butyrate transport across pig and human colonic luminal membrane.The Journal of physiology · 1998Article
- Mass spectrometric determination of HCO3- permeability and carbonic anhydrase activity in intact guinea-pig colon epithelium.The Journal of physiology · 1997Article
- Non-ionic diffusion and carrier-mediated transport drive extracellullar pH regulation of mouse colonic crypts.The Journal of physiology · 1996Article
- Unidirectional fluxes of short-chain fatty acids across segments of the large intestine in pig, sheep and pony compared with guinea pig.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Unidirectional fluxes of propionate across isolated epithelia from the guinea-pig caecum and proximal colon were measured under short-circuit current conditions. In the caecum and proximal colon the serosal-to-mucosal propionate flux (JPrsm) was higher than mucosal-to-serosal flux (JPrms), resulting in a net secretory flux of propionate. 2. HCO3(-)-CO2-free solution reduced JPrms in the caecum and proximal colon markedly; JPrsm was not (caecum) or little (proximal colon) affected. The subsequent addition of acetazolamide caused a further decrease in JPrms in the proximal colon, but not in the caecum. 3. In HCO3(-)-containing solutions acetazolamide or ethoxzolamide inhibited JPrms; JPrsm was not affected. A macromolecular carbonic anhydrase inhibitor, prontosil-dextran, had no effect on propionate fluxes, indicating that the intracellular carbonic anhydrase is of importance for short-chain fatty acid transport. 4. Subsequent to carbonic anhydrase inhibition, mucosal addition of amiloride caused a slight further decrease of JPrms in the caecum and proximal colon; JPrsm was not affected. 5. Results support the view that a considerable proportion of short-chain fatty acids (SCFAs) is absorbed via a SCFA(-)-HCO3- exchange.
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