ArticleThe EMBO journal1994
Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 197 citations in OpenAlex.
- Speed and navigation control of thymocyte development by the fetal T-cell gene regulatory network.Immunological reviews · 2023Review
- Specification of hematopoietic stem cells in mammalian embryos: a rare or frequent event?Blood · 2022Article
- The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.The Journal of experimental medicine · 2019Article
- Identification of a novel lymphoid population in the murine epidermis.Scientific reports · 2015Article
- Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.Molecular and cellular biology · 2014Article
- Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.Nature immunology · 2014Article
- Vitamin C promotes maturation of T-cells.Antioxidants & redox signaling · 2013Article
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.The Journal of experimental medicine · 2013Article
- Global transcriptional analysis of primitive thymocytes reveals accelerated dynamics of T cell specification in fetal stages.Immunogenetics · 2012Article
- Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.Blood · 2012Article
- Article
- Signal integration and crosstalk during thymocyte migration and emigration.Nature reviews. Immunology · 2011Review
- Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.Molecular and cellular biology · 2011Article
- Hematopoietic progenitor migration to the adult thymus.Annals of the New York Academy of Sciences · 2011Review
- From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Immunological reviews · 2010Review
- GATA-3 is required for early T lineage progenitor development.The Journal of experimental medicine · 2009Article
- The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man.Seminars in immunopathology · 2008Review
- Extrinsic and intrinsic regulation of early natural killer cell development.Immunologic research · 2008Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotype and commitment of thymus-colonizing precursors are unknown. Here we report the identification of T lineage-committed precursors (designated prothymocytes) in murine fetal blood at day 15.5 of development. Fetal blood pro-thymocytes are Thy-1+c-kit(low)CD3- in contrast to fetal blood-derived pluripotent hematopoietic progenitors which are Thy-1-c-kit+. Upon transfer into the thymus, fetal blood pro-thymocytes generate a single wave of CD4+CD8+ thymocytes and subsequently mature TCR alpha beta+ peripheral T cells. However, fetal blood pro-thymocytes lack multipotent progenitor potential since they fail to reconstitute B lymphocytes and myeloid and erythroid lineages. In contrast, T and B lymphocytes as well as myeloid and erythroid lineages are reconstituted from fetal blood-derived pluripotent progenitors. Pro-thymocytes are equally present in peripheral blood of athymic fetal mice, suggesting that this novel precursor population is T lineage-committed prior to thymus colonization and represents the earliest T lineage precursor identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.