ArticleHistochemistry1994
CD44 variant isoforms are preferentially expressed in basal epithelial of non-malignant human fetal and adult tissues.
Article in Histochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 136 citations in OpenAlex.
- The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development.Cancer biology & therapy · 2023Article
- Targeting epithelium-expressed sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis.JCI insight · 2020Article
- An Immunohistochemical Study of Gastric Mucosa and Critical Review Indicate that the Subepithelial Telocytes are Prelymphatic Endothelial Cells.Medicina (Kaunas, Lithuania) · 2019Article
- Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods.Stem cells international · 2019Review
- Gene expression in salivary glands: effects of diet and mouse chromosome 17 locus regulating macronutrient intake.Physiological reports · 2015Article
- Evaluation of soluble CD44 protein marker to distinguish the premalignant and malignant carcinoma cases in cervical cancer patients.Medical oncology (Northwood, London, England) · 2014Article
- Article
- Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT).Seminars in cancer biology · 2012Review
- Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder.Histochemistry and cell biology · 2008Article
- Cell type-specific analyses for identifying prostate cancer biomarkers.Current urology reports · 2006Review
- Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer.British journal of cancer · 2005Article
- CD44 in cancer progression: adhesion, migration and growth regulation.Journal of molecular histology · 2004Review
- CD44 cell adhesion molecules.Molecular pathology : MP · 1999Review
- Article
- Up-regulation of CD44 variant exon expression in endometrial carcinomas: analysis of mRNA and protein isoforms, and relation to clinicopathological factors.Japanese journal of cancer research : Gann · 1998Article
- Cell-cell interaction in prostate gene regulation and cytodifferentiation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- CD44 and the adhesion of neoplastic cells.Molecular pathology : MP · 1997Review
- Serum levels of soluble CD44 variant isoforms are elevated in rheumatoid arthritis.Rheumatology international · 1997Article
- High serum levels of soluble CD44 variant isoform v5 are associated with favourable clinical outcome in ovarian cancer.British journal of cancer · 1997Article
- CD44 isoform expression in the diffuse neuroendocrine system. I. Normal cells and hyperplasia.Histochemistry and cell biology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD44 is a transmembrane glycoprotein, which can exist in a multitude of isoforms due to alternative splicing of the pre-mRNA. We have generated monoclonal antibodies to several of these variant regions, which are encoded by 10 additional exons in the extracellular part of the molecule. CD44 variant isoforms have been reported to be involved in the malignant progression of rat and human tumours. The precise localization of CD44 variant isoforms in normal developmental and morphogenetic processes is essential for diagnostic studies of human tumorigenesis. Therefore, we have analysed a large number of different human tissues by immunohistochemistry for the expression of CD44 isoforms containing either exons 4v, 6v or 9v. Expression of exon 9v-isoforms was detected in almost all epithelia analysed, with a few exceptions. Exon 6v isoforms are expressed only in squamous and glandular epithelial, e.g. skin epidermis, sweat and sebaceous glands, oesophagus, ducts of the mammary gland, salivary and prostate glands. Detection of exon 4v-encoded isoforms was restricted to the epidermis and the oesophagus. Similar tissue distributions of CD44 variant isoforms were observed in 10-week-old fetal tissues. Since one of the ligands of CD44 is hyaluronic acid (HA), we also analysed the tissue distribution of HA synthetase. HA synthetase was detected in all tissues analysed, showing good correlation with the expression of the standard form of CD44, CD44s.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.