ArticleCalcified tissue international1994
Alterations in glycosaminoglycan concentration and sulfation during chondrocyte maturation.
Article in Calcified tissue international, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors.International journal of molecular sciences · 2023Article
- Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation.Frontiers in cell and developmental biology · 2022Article
- Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.Pediatric nephrology (Berlin, Germany) · 2013Review
- Changes in mechanics and composition of human talar cartilage anlagen during fetal development.Osteoarthritis and cartilage · 2011Article
- Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.PLoS genetics · 2011Article
- Gender-specific distribution of glycosaminoglycans during cartilage mineralization of human thyroid cartilage.Journal of anatomy · 2004Article
- The biochemical characterization of aggrecan from normal and tibial-dyschondroplastic chicken growth-plate cartilage.The Biochemical journal · 2000Article
- Lack of chondroitin sulphate epitope in the proliferating zone of the growth plate of chicken tibia.The Histochemical journal · 1996Article
- Differentiation and mineralization in chick chondrocytes maintained in a high cell density culture: a model for endochondral ossification.In vitro cellular & developmental biology. Animal · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used antibodies to chondroitin 4- and 6-sulfate and keratan sulfate along with Alcian blue staining of sulfated proteoglycans to investigate changes in content and sulfation within the avian growth plate. In normal chicks, chondroitin 4- and 6-sulfate content were similar in the proliferating and transitional zones but in the hypertrophic zone, chondroitin 4- and 6-sulfate were slightly lower (13% and 18%, respectively) and keratan sulfate was markedly lower (58%). Compared with the proliferative zone, Alcian blue staining of sulfated glycosaminoglycans was markedly lower in both the transitional (46%) and hypertrophic (22%) zones. In tibial dyschondroplasia, where chondrocyte maturation is arrested at the transitional zone, there was no difference in the chondroitin 4- and 6-sulfate or keratan sulfate staining between the proliferative and transitional zones, which were similar to normal birds. With Alcian blue staining there was no difference in the intensity of the staining within the proliferating zone compared with normal birds but staining in the transitional chondrocytes was markedly higher (39%). These results suggest that in the early steps of chondrocyte maturation there may be a decrease in the degree of glycosaminoglycan sulfation without any alteration in glycosaminoglycan concentration, and that further maturation may be accompanied by a change in the nature of the proteoglycans which may also affect the level of sulfation.
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