ArticleCell and tissue research1994
Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description.
Article in Cell and tissue research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 118 citations in OpenAlex.
- Functional role of the enteric nervous system in poultry intestinal health and production.Poultry science · 2026Review
- APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease.Biomolecules · 2023Review
- Immunodetection of P2X2 Receptor in Enteric Nervous System Neurons of the Small Intestine of Pigs.Animals : an open access journal from MDPI · 2022Article
- Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide.Neurogastroenterology and motility · 2015Article
- Excitatory and inhibitory enteric innervation of horse lower esophageal sphincter.Histochemistry and cell biology · 2015Article
- Functional alterations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons.FEBS letters · 2014Article
- Transplanted progenitors generate functional enteric neurons in the postnatal colon.The Journal of clinical investigation · 2013Article
- Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus.The Journal of physiology · 2011Article
- Inhibitory neuromuscular transmission to ileal longitudinal muscle predominates in neonatal guinea pigs.Neurogastroenterology and motility · 2010Article
- Nitric oxide enhances inhibitory synaptic transmission and neuronal excitability in Guinea-pig submucous plexus.Frontiers in neuroscience · 2010Article
- Development of enteric neuron diversity.Journal of cellular and molecular medicine · 2009Review
- Effects of combined pre- and post-natal protein deprivation on the myenteric plexus of the esophagus of weanling rats: a histochemical, quantitative and ultrastructural study.World journal of gastroenterology · 2007Article
- Transient expression of NOS-II during development of the murine enteric nervous system.Journal of molecular histology · 2004Article
- Myenteric nitrergic neurons along the rat esophagus: evidence for regional and strain differences in age-related changes.Histochemistry and cell biology · 2003Article
- Article
- Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.British journal of pharmacology · 1999Article
- Distribution of NADPH diaphorase-positive neurons in the enteric nervous system of the rabbit intestine.Neurochemical research · 1998Article
- The innervation of rainbow trout (Oncorhynchus mykiss) liver: protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities.Journal of anatomy · 1998Article
- The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine.Journal of anatomy · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution and abundance of nitric oxide synthase (NOS)-containing neurons and their terminals in the gastrointestinal tract of the guinea-pig were examined in detail using NADPH diaphorase histochemistry and NOS immunohistochemistry. NOS-containing cell bodies were found in the myenteric plexus throughout the gastrointestinal tract and in the submucous plexus of the stomach, colon and rectum. NOS-containing neurons comprised between 12% (in the duodenum) and 54% (in the esophagus) of total myenteric neurons. In the ileum, NOS neurons represented 19% of total myenteric neurons. Most of the NOS neurons throughout the gastrointestinal tract possessed lamellar dendrites and a single axon. NOS-containing terminals were abundant in the circular muscle, including that of the sphincters, but were rare in the longitudinal muscle, except for the taeniae of the caecum. The muscularis mucosae of the esophagus, stomach, colon and rectum received a medium to dense innervation by NOS terminals. Within myenteric ganglia, NOS-containing terminals were extremely sparse in the esophagus, stomach and duodenum, common in the ileum and distal colon and extremely dense in the proximal colon and rectum. The submucous plexus in the ileum and large intestine contained a sparse plexus of NOS-containing terminals. NOS terminals were not observed in the mucosa of any region. We conclude that throughout the gastrointestinal tract of the guinea-pig, NOS neurons are inhibitory motor neurons to the circular muscle; in the ileum and large intestine, NOS neurons may also function as interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.