ArticleBritish journal of cancer1994
Expression of tumour necrosis factor alpha and its receptors in carcinoma of the breast.
Article in British journal of cancer, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- Partners in crime: TNFα-based networks promoting cancer progression.Cancer immunology, immunotherapy : CII · 2020Review
- Interleukin-17 and matrix metalloprotease-9 expression in the mycetoma granuloma.PLoS neglected tropical diseases · 2019Article
- Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents.Brain, behavior, and immunity · 2015Review
- The Tumor-Promoting Flow of Cells Into, Within and Out of the Tumor Site: Regulation by the Inflammatory Axis of TNFα and Chemokines.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- Comparative immunohistochemical analysis of angiogenesis and mast cell density in oral normal mucosa and squamous cell carcinoma.Dental research journal · 2012Article
- The expression of interleukin (IL)-17 and IL-17 receptor and MMP-9 in human pituitary adenomas.Pituitary · 2011Article
- The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.Immunology · 2011Review
- Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition.BMC cancer · 2011Article
- Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival.International journal of oncology · 2010Article
- Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis.World journal of surgery · 2010Article
- Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization.PloS one · 2009Article
- Expression of endoglin (CD105) in cervical cancer.British journal of cancer · 2009Article
- IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines.Breast cancer research : BCR · 2008Article
- Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL-2-mediated neovascularization.British journal of cancer · 2000Article
- Expression of tumor necrosis factor-alpha and interleukin-6 in oral squamous cell carcinoma.Japanese journal of cancer research : Gann · 1999Article
- Potential angiogenic role of platelet-activating factor in human breast cancer.The American journal of pathology · 1998Article
- Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma.British journal of cancer · 1998Article
- Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.Molecular and cellular biology · 1997Article
- Cytokines in tumour growth, migration and metastasis.World journal of urology · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of tumour necrosis factor alpha (TNF-alpha) and its two distinct receptors, TNF-R p55 and TNF-R p75, was assessed by immunocytochemistry in 28 primary breast cancer and three reduction mammoplasty specimens ('normal' breast tissue). Expression of TNF-alpha or TNF-R p75 was not detectable in normal breast tissue or in non-malignant breast tissue adjacent to the tumours. By contrast, TNF-R p55 was expressed by occasional stromal cells in normal tissue. TNF-alpha was expressed focally in 50% of the tumours studied, being largely localised to macrophage-like cells in the stroma. TNF-R p55 was expressed by a population of stromal cells in all the tumours examined, and a varying proportion of neoplastic cells in 75% of these tissues. TNF-R p75 was detected in about 70% of the tumours, immunoreactivity being confined mainly to cells in the stroma. In this preliminary study there was no association between the above cytokine parameters and such measures of tumour biology as lymph node status, tumour grade, proliferative activity or degree of angiogenesis. However, there was a correlation between the expression of TNF-R p55 by blood vessels and the number of leucocytes present.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.