ArticleProceedings of the National Academy of Sciences of the United States of America1994
Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Association of GenesInternational journal of molecular sciences · 2025Article
- Prolactin: A Key Immunoregulator in Viral Infections and Autoimmune Diseases.International journal of endocrinology · 2025Review
- JAK/STAT pathway and molecular mechanism in bone remodeling.Molecular biology reports · 2020Review
- The role of the JAK-STAT pathway in neural stem cells, neural progenitor cells and reactive astrocytes after spinal cord injury.Biomedical reports · 2015Article
- Article
- Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα(+) tumorigenesis.Cell death and differentiation · 2014Article
- Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports.Genes & development · 2012Article
- Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.American journal of physiology. Cell physiology · 2009Article
- Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes.Oncogene · 2000Review
- Control of normal mammary epithelial phenotype by integrins.Journal of mammary gland biology and neoplasia · 1998Review
- Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells.The Biochemical journal · 1997Article
- Prolactin as a mitogen in mammary cells.Journal of mammary gland biology and neoplasia · 1997Review
- Prolactin mediated intracellular signaling in mammary epithelial cells.Journal of mammary gland biology and neoplasia · 1997Review
- Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin.The Biochemical journal · 1996Article
- Prolactin increases CD4/CD8 cell ratio in thymus-grafted congenitally athymic nude mice.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway.The Journal of clinical investigation · 1996Article
- Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells.Breast cancer research and treatment · 1996Article
- Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Thrombopoietin activates a STAT5-like factor in hematopoietic cells.The EMBO journal · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prolactin (PRL) receptor is a member of the family of cytokine receptors that lack intrinsic tyrosine kinase activity but contain two conserved cysteines in their N-terminal regions and a WSXWS motif adjacent to their transmembrane domains. In a manner similar to the interferons (IFNs), exposure of cells to PRL results in tyrosine phosphorylation of several cellular proteins and the rapid transcriptional induction of the IFN regulatory factor 1 gene. In this communication, we demonstrate that treatment of rat Nb2 lymphoma cells with PRL activates a latent protein factor so that it binds to an enhancer in the IFN regulatory factor 1 gene. This enhancer has been shown to be required for IFN-gamma-activated expression of this gene. PRL-induced assembly of the DNA binding complex, PRL-stimulated factor, required tyrosine phosphorylation. PRL-stimulated factor contained at least one protein that was antigenically similar to the p91 transcription factor, a component of several transcription complexes required for cytokine-activated gene expression. PRL not only induced the tyrosine phosphorylation of p91 but also induced tyrosine phosphorylation of Jak2, a tyrosine kinase required for IFN-gamma-activated gene expression. These results provide evidence for a signaling mechanism, some of whose components are shared by both PRL and IFN-gamma receptors, that results in the expression of early response genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.