ArticleThe Journal of clinical investigation1994
Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.
- 100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies.European journal of nutrition · 2021Pooled it
- Optical molecular imaging technology and its application in precise surgical navigation of liver cancer.Theranostics · 2025Review
- Role of Advanced Glycation End Products and Its Receptors in the Pathogenesis of Cigarette Smoke-Induced Cardiovascular Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015Review
- Oxidative stress as a mechanism of added sugar-induced cardiovascular disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2014Review
- Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection.Journal of lipid research · 2013Review
- Article
- Antioxidant vitamins and their use in preventing cardiovascular disease.Molecules (Basel, Switzerland) · 2010Review
- Impaired graft healing due to hypercholesterolemia is prevented by dietary supplementation with alpha-tocopherol.Journal of vascular surgery · 2008Article
- Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Article
- Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides.Inflammation · 2003Article
- Oxidative stress, alpha-tocopherol therapy, and atherosclerosis.Current atherosclerosis reports · 2002Review
- Vitamin E: action, metabolism and perspectives.Journal of physiology and biochemistry · 2001Review
- Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data.Lipids · 2001Review
- Effects of vitamin E on human platelet and mononuclear cell responses in vitro.International journal of experimental pathology · 1999Article
- Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages.Lipids · 1998Article
- Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.The Journal of clinical investigation · 1997Article
- Prevention of pancreatic islet xenograft rejection by dietary vitamin E.The American journal of pathology · 1997Article
- Vitamin E potentiates arachidonate release and phospholipase A2 activity in rat heart myoblastic cells.The Biochemical journal · 1996Article
- The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.The Journal of clinical investigation · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antioxidants have been proposed to be anti-atherosclerotic agents; however, the mechanisms underlying their beneficial effects are poorly understood. We have examined the effect of alpha-tocopherol (alpha-tcp) on one cellular event in atherosclerotic plaque development, monocyte adhesion to stimulated endothelial cells (ECs). Human umbilical vein ECs were pretreated with alpha-tcp before stimulation with known agonists of monocyte adhesion: IL-1 (10 ng/ml), LPS (10 ng/ml), thrombin (30 U/ml), or PMA (10 nM). Agonist-induced monocytic cell adhesion, but not basal adhesion, was inhibited in a time- and concentration-dependent manner by alpha-tcp. The IC50 of alpha-tcp on an IL-1-induced response was 45 microM. The inhibition correlated with a decrease in steady state levels of E-selectin mRNA and cell surface expression of E-selectin which is consistent with the ability of a monoclonal antibody to E-selectin to inhibit monocytic cell adhesion in this system. Probucol (50 microM) and N-acetylcysteine (20 mM) also inhibited agonist-induced monocytic cell adhesion; whereas, several other antioxidants had no significant effect. Protein kinase C (PKC) does not appear to play a role in the alpha-tcp effect since no suppression of phosphorylation of PKC substrates was observed. Activation of the transcription factor NF-kappa B is reported to be necessary but not sufficient for E-selectin expression in EC. Electrophoretic mobility shift assays failed to show an alpha-tcp-induced decrease in activation of this transcription factor after cytokine stimulation. It has been hypothesized that alpha-tcp acts as an anti-atherosclerotic molecule by inhibiting generation of oxidized LDL--a putative triggering molecule in the atherosclerotic process. Our results point to a novel alternative mechanism of action of alpha-tcp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.