ArticleHistochemistry1994
Colocalization of cytokeratin 18 and villin in type III alveolar cells (brush cells) of the rat lung.
Article in Histochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Protocadherin 20 Is a POU Class 2 Homeobox 3 Target Gene Required for Proper Tuft Cell Microvillus Organization.Cellular and molecular gastroenterology and hepatology · 2026Article
- Organization of a cytoskeletal superstructure in the apical domain of intestinal tuft cells.The Journal of cell biology · 2024Article
- Alveolar-Capillary Barrier Protection In Vitro: Lung Cell Type-Specific Effects and Molecular Mechanisms Induced by 1α, 25-Dihydroxyvitamin D3.International journal of molecular sciences · 2023Article
- Thymic epithelial cell heterogeneity: TEC by TEC.Nature reviews. Immunology · 2020Review
- The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Immunohistochemical characterization of brush cells in the rat larynx.Journal of molecular histology · 2018Article
- Lithium chloride's inhibition of 3T3-L1 cell differentiation by regulating the Wnt/β-catenin pathway and enhancing villin 2 expression.Food science and biotechnology · 2016Article
- The intestinal epithelium tuft cells: specification and function.Cellular and molecular life sciences : CMLS · 2012Review
- "Tasting" the airway lining fluid.Histochemistry and cell biology · 2012Review
- Gastric tuft cells express DCLK1 and are expanded in hyperplasia.Histochemistry and cell biology · 2011Article
- TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells.BMC neuroscience · 2007Article
- Brush cells in the human duodenojejunal junction: an ultrastructural study.Journal of anatomy · 2007Article
- The mysterious pulmonary brush cell: a cell in search of a function.American journal of respiratory and critical care medicine · 2005Review
- A new fate for old cells: brush cells and related elements.Journal of anatomy · 2005Review
- Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Cytoskeletal markers allowing discrimination between brush cells and other epithelial cells of the gut including enteroendocrine cells.Histochemistry and cell biology · 1996Article
- Expression of CD44 isoforms during bleomycin-or radiation-induced pulmonary fibrosis in rats and mini-pigs.Histochemistry and cell biology · 1996Article
- Immunocytochemical distribution of E-cadherin in normal and injured lung tissue of the rat.Histochemistry and cell biology · 1995Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveoli of the rat lung are lined by three different cell types, the flat type I cells and the cuboidal type II and type III cells. Type III cells differ from type II cells by the presence of an apical tuft of microvilli and the absence of lamellar type secretory granules. In the present study we show by double immunolabelling that type III cells of the rat lung can be identified at the light- and electron microscope level by antibodies against both cytokeratin 18 and the actin-crosslinking protein villin. At the ultrastructural level, microvilli and their rootlets in the apical cytoplasm were labelled by the anti-villin antibodies, whereas a monoclonal antibody against cytokeratin 18 (Ks18.04) labelled bundles of intermediate filaments. In conclusion, antibodies against villin and certain monoclonal antibodies specific for cytokeratin 18 can be used as tools for selective visualization of type III cells in the rat lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.