ArticleCell and tissue research1994
Cytokeratin 18 is an M-cell marker in porcine Peyer's patches.
Article in Cell and tissue research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- Increased number of intestinal villous M cells in levamisole -pretreated weaned pigs experimentally infected with F4ac⁺ enterotoxigenic Escherichia coli strain.European journal of histochemistry : EJH · 2010Trial
- Goblet Cells and Mucus Composition in Jejunum and Ileum Containing Peyer's Patches and in Colon: A Study in Pigs.Animals : an open access journal from MDPI · 2025Article
- Modulation of cytokeratin and cytokine/chemokine expression following influenza virus infection of differentiated human tonsillar epithelial cells.Journal of virology · 2025Article
- Characterization of Canine Peyer's Patches by Multidimensional Analysis: Insights from Immunofluorescence, Flow Cytometry, and Single-Cell RNA Sequencing.ImmunoHorizons · 2023Article
- Regional epithelial cell diversity in the small intestine of pigs.Journal of animal science · 2023Article
- Establishment of bovine 3D enteroid-derived 2D monolayers.Veterinary research · 2022Article
- Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer's patches.Scientific reports · 2022Article
- Investigation of Early Supplementation of Nucleotides on the Intestinal Maturation of Weaned Piglets.Animals : an open access journal from MDPI · 2021Article
- The pig as a model for immunology research.Cell and tissue research · 2020Review
- Organogenesis of Ileal Peyer's Patches Is Initiated Prenatally and Accelerated Postnatally With Comprehensive Proliferation of B Cells in Pigs.Frontiers in immunology · 2020Article
- Identifying human and murine M cells in vitro.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Impact of TGEV infection on the pig small intestine.Virology journal · 2018Article
- Review
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Article
- Roles of M cells in infection and mucosal vaccines.Human vaccines & immunotherapeutics · 2014Review
- C6, a new monoclonal antibody, reacts with the follicle-associated epithelium of calf ileal Peyer's patches.Journal of veterinary science · 2013Article
- Distribution, organization and innervation of gastric MALT in conventional piglet.Journal of anatomy · 2011Article
- The identification of intestinal M cells in the sacculus rotundus and appendix of the Angora rabbit.Veterinary research communications · 2010Article
- Intestinal M cells: the fallible sentinels?World journal of gastroenterology · 2007Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermediate filaments of the dome epithelium of porcine Peyer's patches were studied by immunohistochemistry. The labelling patterns of monospecific antibodies directed against cytokeratins 8, 18 and 19 differed considerably. About 40% of the dome epithelial cells were intensely labelled by three different anti-cytokeratin 18 antibodies, indicating that large amounts of cytokeratin 18 are present in these cells. In order to verify that these cytokeratin-18-immunoreactive cells were M-cells, uptake studies using fluorescein-labelled yeast particles were performed. Numerous yeast particles were found exclusively in dome epithelial cells that were highly positive for cytokeratin 18, thus representing M-cells. In contrast, the content of cytokeratin 19 in M-cells was lower than that in neighbouring enterocytes. The labelling intensity of cytokeratin 8 did not differ between M-cells and enterocytes. In addition, the absence of vimentin and desmin from the dome epithelium of porcine Peyer's patches was demonstrated. The results show (1) that porcine M-cells differ from enterocytes in the composition of their cytoskeleton, (2) that cytokeratin 18 is a useful marker for detecting porcine M-cells and (3) that this marker directly correlates with M-cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.