ArticlePflugers Archiv : European journal of physiology1994
Guanylate-cyclase-mediated inhibition of cardiac ICa by carbachol and sodium nitroprusside.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
- Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.Journal of molecular and cellular cardiology · 2017Article
- Muscarinic regulation of cardiac ion channels.British journal of pharmacology · 2003Review
- Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ventricular myocytes.British journal of pharmacology · 2003Article
- NO donors potentiate the beta-adrenergic stimulation of I(Ca,L) and the muscarinic activation of I(K,ACh) in rat cardiac myocytes.The Journal of physiology · 2002Article
- Local response of L-type Ca(2+) current to nitric oxide in frog ventricular myocytes.The Journal of physiology · 2001Article
- G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes.The Journal of physiology · 2001Article
- Nitric oxide increases persistent sodium current in rat hippocampal neurons.The Journal of physiology · 1999Article
- Deficiency in myocardial NO biosignalling after cardioplegic arrest: mechanisms and contribution to post-storage mechanical dysfunction.British journal of pharmacology · 1999Article
- Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.British journal of pharmacology · 1999Article
- Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart.The Journal of clinical investigation · 1998Article
- Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors.The Journal of physiology · 1998Article
- Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes.The Journal of physiology · 1998Article
- Nitric oxide signaling mediates stimulation of L-type Ca2+ current elicited by withdrawal of acetylcholine in cat atrial myocytes.The Journal of general physiology · 1998Article
- Mediation by nitric oxide of the indirect effects of adenosine on calcium current in rabbit heart pacemaker cells.British journal of pharmacology · 1996Article
- Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.The Journal of general physiology · 1996Article
- Acetylcholine inhibits Ca2+ current by acting exclusively at a site proximal to adenylyl cyclase in frog cardiac myocytes.The Journal of physiology · 1996Article
- Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells.Pflugers Archiv : European journal of physiology · 1996Article
- Regulation of myocardial calcium channels by cyclic AMP metabolism.Basic research in cardiology · 1996Review
- The ineffectiveness of the NO-cyclic GMP signaling pathway in the atrial myocardium.British journal of pharmacology · 1995Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the role of cyclic guanosine monophosphate (cGMP) as a mediator of the reduction of L-type calcium current (ICa) induced by muscarinic receptor stimulation and by nitric oxide in isolated guinea-pig ventricular cells using the whole-cell patch-clamp technique. Our results show that when the level of cyclic adenosine monophosphate was increased by the phosphodiesterase inhibitor isobutylmethylxanthine (IBMX), stimulation of a pertussis-toxin (PTX)-sensitive muscarinic receptor by carbachol (1 microM) reduced the calcium current increase from 80.6 +/- 23.5% to 19.8 +/- 9.6% over the control and this effect was prevented by methylene blue (10 microM), an inhibitor of the soluble guanylate cyclase. Pipette solution containing 10 microM cGMP reduced the enhancement of ICa by IBMX from 121.9 +/- 11.6% to 14.2 +/- 5.4% above the control. Sodium nitroprusside (10 microM), a spontaneous donor of nitric oxide, and consequently a stimulator of soluble guanylate cyclase, also reduced IBMX-stimulated ICa from 115.2 +/- 13.2% to 32.2 +/- 6.9% above control and the sodium nitroprusside effect was also suppressed by methylene blue. The latter two reagents were ineffective on basal ICa.
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