ArticleThe Journal of experimental medicine1994
Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 147 citations in OpenAlex.
- Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis.Clinical science (London, England : 1979) · 2025Article
- Impact of targeting the platelet-activating factor and its receptor in cancer treatment.Military Medical Research · 2025Review
- Classes of Lipid Mediators and Their Effects on Vascular Inflammation in Atherosclerosis.International journal of molecular sciences · 2023Review
- Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.Breast cancer research : BCR · 2018Article
- Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.Pflugers Archiv : European journal of physiology · 2017Review
- Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization.Cell proliferation · 2016Article
- Environmental immune disruptors, inflammation and cancer risk.Carcinogenesis · 2015Review
- Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.Oncoimmunology · 2015Article
- A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis.PloS one · 2013Article
- The cutaneous vascular system in chronic skin inflammation.The journal of investigative dermatology. Symposium proceedings · 2011Review
- Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.American journal of physiology. Cell physiology · 2011Article
- Angiogenin-mediated ribosomal RNA transcription as a molecular target for treatment of head and neck squamous cell carcinoma.Oral oncology · 2010Review
- Angiogenesis drives psoriasis pathogenesis.International journal of experimental pathology · 2009Review
- Emerging roles of PAR-1 and PAFR in melanoma metastasis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2008Article
- Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2.The British journal of ophthalmology · 2007Article
- Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter.The Biochemical journal · 2005Article
- The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.The EMBO journal · 2003Article
- Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction.The Journal of experimental medicine · 2003Article
- The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.The EMBO journal · 2001Article
- PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.The American journal of pathology · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor (TNF) alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Therefore, it was suggested that the angiogenic properties of this agent might be consequent to the production of secondary mediators. Since TNF-alpha stimulates the synthesis of platelet-activating factor (PAF) by monocytes and endothelial cells, we investigated the possible involvement of PAF in the angiogenic effect of TNF-alpha. Angiogenesis was studied in a murine model in which Matrigel was used as a vehicle for the delivery of mediators. In this model the angiogenesis induced by TNF-alpha was shown to be inhibited by WEB 2170, a specific PAF receptor antagonist. Moreover, in mice injected with TNF-alpha, PAF was detected within the Matrigel, 6 and 24 h after TNF-alpha injection. The synthesis of PAF within the Matrigel was concomitant with the early migration of endothelial cells and infiltration of monocytes. No infiltration of lymphocytes or polymorphonuclear leukocytes was observed. Synthetic PAF as well as PAF extracted and purified from mice challenged with TNF-alpha induced a rapid angiogenic response, inhibited by WEB 2170. These results suggest that the angiogenic effect of TNF-alpha is, at least in part, mediated by PAF synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.