ArticleInflammation1994
Inhibition of angiogenesis in rats by IL-1 receptor antagonist and selected cytokine antibodies.
Article in Inflammation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 39 citations in OpenAlex.
- Construction of a disulfide-stabilized diabody against fibroblast growth factor-2 and the inhibition activity in targeting breast cancer.Cancer science · 2016Article
- Effect of manipulation of primary tumour vascularity on metastasis in an adenocarcinoma model.British journal of cancer · 2002Article
- The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma.Journal of leukocyte biology · 2000Article
- Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants.British journal of pharmacology · 1996Article
- Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model.British journal of pharmacology · 1996Article
- Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat.Inflammation · 1995Article
- Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A.British journal of pharmacology · 1995Article
- The role of IL-1 in the pathogenesis of heart disease.Archivum immunologiae et therapiae experimentalisReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Daily administration of 50 ng recombinant human interleukin 1-alpha (IL-1 alpha), 25 ng IL-8, 50 ng tumor necrosis factor-alpha (TNF-alpha), or 100 ng basic fibroblast growth factor (bFGF) caused intense neovascularization in a rat sponge model. These cytokine-induced neovascular responses were inhibited by coadministration of IL-1 receptor antagonist (IL-1ra; 50 micrograms), IL-8 antiserum (IL-8-AS; 1: 1000), TNF-alpha antibody (TNF-AB; 500 ng), or a monoclonal antibody to bFGF (DG2; 1000 ng), respectively. These data suggest that it is possible to manipulate the angiogenic response elicited by a defined cytokine by its receptor antagonist or neutralizing antibody. In the absence of exogenous cytokines, the sponge-induced angiogenesis was profoundly suppressed by dexamethasone (5 micrograms/day), but not modified by IL-1ra, IL-8-AS, TNF-AB, and DG2 alone. However, the combination of these four reagents was able to inhibit the sponge-induced neovascular response almost completely. These findings provide direct evidence that IL-1 alpha, IL-8, TNF-alpha and/or bFGF have an intrinsic role in angiogenesis. Further work is necessary to characterize the profile of these cytokines during angiogenesis and to elucidate the nature of their interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.