ArticleProceedings of the National Academy of Sciences of the United States of America1994
A conserved heptamer motif for ribosomal RNA transcription termination in animal mitochondria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 61 citations in OpenAlex.
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- The first complete mitochondrial genome ofGigaByte (Hong Kong, China) · 2022Article
- Characterization and Comparative Analyses of Mitochondrial Genomes in Single-Celled Eukaryotes to Shed Light on the Diversity and Evolution of Linear Molecular Architecture.International journal of molecular sciences · 2021Article
- Complete mitochondrial genome and phylogenetic analysis of willow ptarmigan (Mitochondrial DNA. Part B, Resources · 2017Article
- Rates and relations of mitochondrial genome evolution across the Echinoidea, with special focus on the superfamily Odontophora.Ecology and evolution · 2017Article
- Article
- Modeling RNA polymerase interaction in mitochondria of chordates.Biology direct · 2012Article
- Tick-box for 3'-end formation of mitochondrial transcripts in Ixodida, basal chelicerates and Drosophila.PloS one · 2012Article
- Characterization of mitochondrial mRNAs in codfish reveals unique features compared to mammals.Current genetics · 2011Article
- Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages.Journal of molecular evolution · 2009Article
- Complete mitochondrial DNA sequence of oyster Crassostrea hongkongensis-a case of "Tandem duplication-random loss" for genome rearrangement in Crassostrea?BMC genomics · 2008Article
- Mitochondrial nuclear receptors and transcription factors: who's minding the cell?Journal of neuroscience research · 2008Review
- Novel mitochondrial gene content and gene arrangement indicate illegitimate inter-mtDNA recombination in the chigger mite, Leptotrombidium pallidum.Journal of molecular evolution · 2005Article
- Article
- Complete mtDNA of Ciona intestinalis reveals extensive gene rearrangement and the presence of an atp8 and an extra trnM gene in ascidians.Journal of molecular evolution · 2004Article
- Transcript mapping and genome annotation of ascidian mtDNA using EST data.Genome research · 2003Article
- DmTTF, a novel mitochondrial transcription termination factor that recognises two sequences of Drosophila melanogaster mitochondrial DNA.Nucleic acids research · 2003Article
- Complete sequence and gene organization of the mitochondrial genome of the land snail Albinaria coerulea.Genetics · 1995Article
- The complete mitochondrial DNA sequence of the crustacean Artemia franciscana.Journal of molecular evolution · 1994Article
- Complete mitochondrial DNA sequence of the eastern oyster Crassostrea virginica.Marine biotechnology (New York, N.Y.)Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A search of sequence data bases for a tridecamer transcription termination signal, previously described in human mtDNA as being responsible for the accumulation of mitochondrial ribosomal RNAs (rRNAs) in excess over the rest of mitochondrial genes, has revealed that this termination signal occurs in equivalent positions in a wide variety of organisms from protozoa to mammals. Due to the compact organization of the mtDNA, the tridecamer motif usually appears as part of the 3' adjacent gene sequence. Because in phylogenetically widely separated organisms the mitochondrial genome has experienced many rearrangements, it is interesting that its occurrence near the 3' end of the large rRNA is independent of the adjacent gene. The tridecamer sequence has diverged in phylogenetically widely separated organisms. Nevertheless, a well-conserved heptamer--TGGCAGA, the mitochondrial rRNA termination box--can be defined. Although extending the experimental evidence of its role as a transcription termination signal in humans will be of great interest, its evolutionary conservation strongly suggests that mitochondrial rRNA transcription termination could be a widely conserved mechanism in animals. Furthermore, the conservation of a homologous tridecamer motif in one of the last 3' secondary loops of nonmitochondrial 23S-like rRNAs suggests that the role of the sequence has changed during mitochondrial evolution.
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