ArticleProceedings of the National Academy of Sciences of the United States of America1994
Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 94 citations in OpenAlex.
- Endemic Kaposi's Sarcoma.Cancers · 2023Review
- An Insight into the Angiogenic and Lymphatic Interplay in Pre-eclampsia Comorbid with HIV Infection.Current hypertension reports · 2020Review
- Kaposi's sarcoma and its associated herpesvirus.Nature reviews. Cancer · 2010Review
- Review
- Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy.The British journal of ophthalmology · 2000Article
- Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells.The American journal of pathology · 2000Article
- Article
- Phenotypic alterations in Kaposi's sarcoma cells by antisense reduction of perlecan.Pathology oncology research : POR · 2000Article
- Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.Journal of virology · 1998Article
- Scatter factor protein levels in human breast cancers: clinicopathological and biological correlations.The American journal of pathology · 1996Article
- Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Kaposi's sarcoma tumor cells preferentially express Bcl-xL.The American journal of pathology · 1996Article
- Charting a new course through the chaos of KS (Kaposi's sarcoma)The American journal of pathology · 1996Review
- Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma.The American journal of pathology · 1996Article
- Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.The Journal of clinical investigation · 1995Article
- The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.The Journal of cell biology · 1995Review
- Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.The Journal of cell biology · 1994Review
- Regulation of scatter factor production via a soluble inducing factor.The Journal of cell biology · 1994Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Kaposi sarcoma (KS) is a complex multicellular neoplasm that is commonly associated with AIDS. The pathogenesis of KS is not well understood. KS tumor cells grow poorly in vitro and require medium conditioned by retrovirus-infected T lymphocytes. We observed that conditioned medium (CM) from type II human T-cell leukemia virus (HTLV-II)-infected T cells (HTLV-II CM) induces conversion of endothelial cells (ECs) to a KS tumor cell-like phenotype. ECs grown in HTLV-II CM acquired a spindle-shaped morphology, the ability to express factor XIIIa and other KS cell markers, and a cytokine production profile similar to that of KS cells. We found that HTLV-II CM contains large quantities of scatter factor (SF), an angiogenic cytokine that stimulates cell motility. SF induced ECs to become spindle-shaped and express factor XIIIa. Moreover, SF was found to be a mitogen for KS cells in vitro and was identified within KS lesions in vivo. SF mRNA was present in KS cells in vitro, and antibodies against SF inhibited the growth of KS cells. The receptor for SF, the c-met protein, was expressed by ECs, dermal dendrocytes, and KS tumor cells in vitro and in vivo. HTLV-II CM was highly angiogenic in vivo, which was blocked by antibodies against SF. Based on these findings, we suggest that SF plays a role in the initiation and maintenance of KS lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.