Evidence map›Paper›PMID 7514516›Full record

ArticleClinical and experimental immunology1994

Circulating adhesion molecules in sarcoidosis.

A S Hamblin, Z Shakoor, P Kapahi, D Haskard

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes.American journal of respiratory cell and molecular biology · 2011
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A S HamblinDepartment of Immunology, United Medical School, St Thomas' Hospital, London, UK.
Z Shakoor
P Kapahi
D Haskard
Hammersmith Hospital · GBSt Thomas' Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Sarcoidosis is a disease of unknown etiology characterized by non-caseating granulomata together with a number of systemic abnormalities. We have recently shown these include increased expression of the integrins CD11/CD18 on peripheral blood leucocytes. Here we have measured serum levels of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in 23 patients and 14 normal controls using antigen capture sandwich ELISAs. Median circulating E-selectin levels in the patients were nearly three times those of the controls (P < 0.0001, Mann-Whitney U-test), whilst ICAM-1 but not VCAM-1 levels were only slightly elevated. These results show that endothelial cell activation and shedding of E-selectin into the circulation are additional features of the pathology of sarcoidosis.

Indexed as

AdultAntigens, CDCD11 AntigensCD18 AntigensCell Adhesion MoleculesE-SelectinFemaleHumansIntercellular Adhesion Molecule-1LeukocytesMaleMiddle AgedReceptors, Leukocyte-AdhesionSarcoidosisVascular Cell Adhesion Molecule-1Antigens, CDCD11 AntigensCD18 AntigensCell Adhesion MoleculesE-SelectinIntercellular Adhesion Molecule-1Receptors, Leukocyte-AdhesionVascular Cell Adhesion Molecule-1

Identifiers

PMID7514516
PMCPMC1534875
OpenAlexW2026060880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.