ArticleProceedings of the National Academy of Sciences of the United States of America1994
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Ibrutinib inhibits pre-BCRBlood · 2017Article
- Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.Immunology and cell biology · 2012Article
- B cells and autoimmunity.Current opinion in immunology · 2011Review
- Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.Leukemia · 2010Article
- Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses.Infection and immunity · 2006Article
- Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.Molecular and cellular biology · 2005Article
- CTLA-4 and tolerance: the biochemical point of view.Immunologic research · 2003Review
- Positive and negative selection during B lymphocyte development.Immunologic research · 2003Review
- Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.The Journal of experimental medicine · 2001Article
- Ligand-dependent and -independent processes in B-cell-receptor-mediated signaling.Springer seminars in immunopathology · 2001Review
- X-linked agammaglobulinemia.Clinical reviews in allergy & immunology · 2000Review
- Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements.The Journal of experimental medicine · 2000Article
- Signal transduction through mu kappa B-cell receptors expressed on pre-B cells is different from that through B-cell receptors on mature B cells.Immunology · 1996Article
- Fate of surrogate light chains in B lineage cells.The Journal of experimental medicine · 1996Article
- Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proteins that bind to discrete domains of the Blk, Fyn, Lyn, and Btk protein tyrosine kinases were examined in pre-B cells that had not been subjected to any external stimulation, as well as in nonstimulated and antigen-receptor-ligated B cells. Proteins that bind to the Src homology 2 domains of Blk and Fyn were identified in B cells that had been activated with anti-IgM but were not identified in unstimulated B cells. A number of Blk and Fyn Src homology 2 domain-binding phosphoproteins were also observed in pre-B cells that had not been stimulated in vitro. The phosphoproteins seen in activated B cells potentially represent substrates that play a role in the pathway of antigen-receptor-mediated signaling. Distinct signaling pathways involving distinguishable kinase substrates may be relevant in pre-B-cell-receptor-mediated cell survival during ontogeny. These results indirectly support models that predict constitutive ligand-independent signaling by the pre-antigen receptor during lymphoid ontogeny.
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