ArticleNucleic acids research1994
A nuclear factor that binds purine-rich, single-stranded oligonucleotides derived from S1-sensitive elements upstream of the CFTR gene and the MUC1 gene.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- MUC1, the renaissance molecule.Journal of mammary gland biology and neoplasia · 2001Review
- Analysis of DNase-I-hypersensitive sites at the 3' end of the cystic fibrosis transmembrane conductance regulator gene (CFTR).The Biochemical journal · 1999Article
- Characterization of a polypurine/polypyrimidine sequence upstream of the mouse metallothionein-I gene.Nucleic acids research · 1998Article
- Molecular cloning and characterization of the gene encoding rat submandibular gland apomucin, Mucsmg.Glycoconjugate journal · 1996Article
- Single-strand-DNA-binding factors specifically recognize the pyrimidine element in the chick alpha2(I) collagen gene promoter.The Biochemical journal · 1996Article
- RNA-dependent DNA binding activity of the Pur factor, potentially involved in DNA replication and gene transcription.Gene expression · 1995Article
- A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have identified two regions of non-random purine/pyrimidine strand asymmetry that were nearly identical in sequence in the 5' flanking (promoter) regions of the human cystic fibrosis transmembrane conductance regulator (CFTR) gene and the human MUC1 gene. These regions contain perfect mirror repeat elements, a sequence motif previously found to be associated with the formation of H-DNA conformations. In this report we demonstrate that a single-stranded non-B DNA conformation exists at low pH in supercoiled plasmids containing the similar mirror repeat elements, and that S1 nuclease digestion maps the single-stranded region to the position of the mirror repeats. In addition, we identify a nuclear protein of approximately 27 kD that binds to single-stranded oligonucleotides corresponding to the purine-rich strand of this region, but not to the pyrimidine-rich strands or to double-stranded oligonucleotides with corresponding purine/pyrimidine strand asymmetry.
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Registered trials
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