ArticleJournal of clinical pathology1994
A new monoclonal antibody (3A5) that recognises a fixative resistant epitope on tissue macrophages and monocytes.
Article in Journal of clinical pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed, 13 citations in OpenAlex.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo develop a monoclonal antibody specific for human macrophages in routinely processed material.
methodsThe monoclonal antibody was derived from a mouse popliteal lymph node after subcutaneous immunisation in the footpad with fragments of human spleen depleted of lymphocytes and erythrocytes.
results3A5 is a monoclonal antibody reactive with macrophages, monocytes, and histiocytes in routinely processed (formalin fixed, paraffin wax embedded) human tissue specimens. Unlike the well known panmacrophage marker KP1 (CD68), neither dendritic cells (interdigitating cells, Langerhans' cells, and microglia) nor myeloid, lymphoid, or epithelial cells stained with 3A5.
conclusionAs the staining pattern of 3A5 is restricted, compared with other macrophage markers and the recognised epitope survives common fixation and embedding procedures, 3A5 is a valuable marker for histiocytes and macrophages in routine diagnostic applications.
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