ArticleThe Journal of experimental medicine1994
Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 142 citations in OpenAlex.
- Adaptive immunity of materials: Implications for tissue healing and regeneration.Bioactive materials · 2024Review
- Study of macrophage functions in murine J774 cells and human activated THP-1 cells exposed to oritavancin, a lipoglycopeptide with high cellular accumulation.Antimicrobial agents and chemotherapy · 2014Article
- Influence of the protein kinase C activator phorbol myristate acetate on the intracellular activity of antibiotics against hemin- and menadione-auxotrophic small-colony variant mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells.Antimicrobial agents and chemotherapy · 2012Article
- Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets.Expert reviews in molecular medicine · 2010Review
- The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.The Journal of cell biology · 2004Article
- FRET detection of cellular alpha4-integrin conformational activation.Biophysical journal · 2003Article
- The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin.Molecular biology of the cell · 2003Article
- Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.The Journal of experimental medicine · 2003Article
- Control of T lymphocyte morphology by the GTPase Rho.BMC cell biology · 2003Article
- Article
- Signal transduction events regulating integrin function and T cell migration: new functions and complexity.Immunologic research · 2003Review
- Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.Immunology · 2002Article
- Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion.Immunology · 2001Article
- Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.The Journal of experimental medicine · 2000Article
- Regulation of integrin function by T cell activation: points of convergence and divergence.Immunologic research · 1999Review
- Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation.The Journal of experimental medicine · 1998Article
- Endothelial cell integrin laminin receptor expression in multiple sclerosis lesions.The American journal of pathology · 1998Article
- Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes.Molecular and cellular biology · 1998Article
- Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function.The Journal of clinical investigation · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We show that the adhesion of T lymphoid cells to immobilized fibronectin can be increased by two distinct mechanisms. The first is by increasing the affinity of the fibronectin receptor/ligand interaction using the anti-beta 1 integrin monoclonal antibody 8A2. The second is by treating the cells with phorbol 12-myristate 13-acetate (PMA), which alters events that occur after receptor occupancy (e.g., cell spreading) without affecting receptor affinity. The effects of these two mechanisms on adhesion in the presence of physiological concentrations of soluble fibronectin suggest that they have different biological consequences. Under these conditions, the net effect of increasing the affinity of the fibronectin receptors is to decrease cell adhesion, whereas the increase in adhesion induced by PMA is unaffected. This suggests that the high affinity receptors are not primarily available for cell adhesion under these circumstances, and that they have an alternative function. We further show that high affinity binding of soluble fibronectin can be induced by either differentiation of the monocytic cell line THP-1 or by cross-linking the T cell receptor complexes on the T lymphoid cell line HUT-78. The differentiated monocytic cells express two populations of fibronectin receptors: a minority in a high affinity state, and the majority in a low affinity state. Thus they will both continue to adhere in the presence of physiological concentrations of soluble fibronectin and bind significant amounts of soluble fibronectin at the cell surface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.