ArticleJournal of virology1994
Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Targeted DNA Demethylation: Vectors, Effectors and Perspectives.Biomedicines · 2023Review
- Article
- Review
- 2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.PloS one · 2013Article
- Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.Virology · 2011Article
- Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.Journal of virology · 2009Article
- Rotavirus Nonstructural Protein NSP3 is not required for viral protein synthesis.Journal of virology · 2006Article
- Cleavage of host keratin 8 by a Chlamydia-secreted protease.Infection and immunity · 2004Article
- Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity.Journal of virology · 2003Article
- Deubiquitinating function of adenovirus proteinase.Journal of virology · 2002Article
- Keratins turn over by ubiquitination in a phosphorylation-modulated fashion.The Journal of cell biology · 2000Article
- Adenovirus induction of an interferon-regulatory factor during entry into the late phase of infection.Journal of virology · 1998Article
- Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors.Journal of neuro-oncology · 1998Article
- Mutational analysis of the human papillomavirus type 16 E1--E4 protein shows that the C terminus is dispensable for keratin cytoskeleton association but is involved in inducing disruption of the keratin filaments.Journal of virology · 1997Article
- Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.Journal of virology · 1997Article
- The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells.Journal of virology · 1996Article
- Crystallization and preliminary X-ray diffraction studies of the human adenovirus serotype 2 proteinase with peptide cofactor.Protein science : a publication of the Protein Society · 1995Article
- Translation-targeted therapeutics for viral diseases.Gene expression · 1995Review
- A late adenovirus factor induces eIF-4E dephosphorylation and inhibition of cell protein synthesis.Journal of virology · 1994Article
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2 authors.
Funding
Abstract
Infection of animal cells by a number of viruses generally results in an array of metabolic defects, including inhibition of host DNA, RNA, and protein synthesis, and morphological alterations known as cytopathic effects. For adenovirus infection there is a profound loss of cell structural integrity and a marked inhibition of host protein synthesis, the latter generally assumed necessary to enhance virus production. We examined the purpose of viral inhibition of cell translation and found that it was related in part to cytopathic wasting of infected cells. We show that viral shutoff of host translation promotes destruction of the intermediate filament network, particularly cytokeratins which are proteolysed at keratins K7 and K18 by the adenovirus late-acting L3 23-kDa proteinase. We found that if adenovirus is prevented from inhibiting cell translation, the intermediate filament network remains relatively intact, keratin proteins are still synthesized, and cells possess an almost normal morphological appearance and lyse poorly, reducing the release of nascent virus particles by several hundredfold. Remarkably, in tissue culture cells the accumulation of late viral structural proteins is only marginally reduced if host translation shutoff does not occur. Thus, a surprising major function for adenovirus inhibition of cellular protein synthesis is to enhance impairment of cellular structural integrity, facilitating cell lysis and release of progeny adenovirus particles.
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