ArticleCell and tissue research1994
Localization of nitric oxide synthase in canine ileocolonic and pyloric sphincters.
Article in Cell and tissue research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Pyloric Dysfunction: A Review of the Mechanisms, Diagnosis, and Treatment.Gut and liver · 2025Review
- Pharmacologic treatments for gastroparesis.Pharmacological reviews · 2025Review
- Targeting the pylorus in gastroparesis: From physiology to endoscopic pyloromyotomy.Neurogastroenterology and motility · 2023Review
- Gastroparesis.Gastroenterology · 2022Review
- Article
- Nitrergic Pathway Is the Main Contributing Mechanism in the Human Gastric Fundus Relaxation: An In Vitro Study.PloS one · 2016Article
- Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon.The Journal of physiology · 2010Article
- Nitric oxide as a modulator of intestinal water and electrolyte transport.Digestive diseases and sciences · 1998Review
- Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats.Digestive diseases and sciences · 1997Article
- Projections of chemically identified myenteric neurons of the small and large intestine of the mouse.Journal of anatomy · 1997Article
- Histochemistry of nitric oxide synthase in the nervous system.The Histochemical journal · 1995Review
- Nitrergic inhibitory innervation of porcine rectal circular smooth muscle.The British journal of surgery · 1995Article
- Ultrastructural investigation of nitric oxide synthase-immunoreactive nerves associated with coronary blood vessels of rat and guinea-pig.Cell and tissue research · 1995Article
- Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description.Cell and tissue research · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The distribution of neurons containing NAD-PH-diaphorase (NADPH-d) activity and nitric oxide synthase-like immunoreactivity (NOS-LI) in the canine pyloric and ileocolonic sphincters was studied. Cells within the myenteric and submucosal ganglia were positive for NADPH-d. These cells generally had the morphology of Dogiel type-I enteric neurons, however, there was some diversity in the morphology of NADPH-d-positive neurons in the myenteric plexus of the pylorus. Intramuscular ganglia were observed in both sphincters, and NADPH-d was found in a sub-population of neurons within these ganglia. Dual staining with an antiserum raised against nitric oxide synthase (NOS) demonstrated that almost all cells with NOS-LI were also NADPH-d positive. Varicose fibers within ganglia and within the circular and longitudinal muscle layers also possed NOS-LI and NADPH-d activity. Dual staining with anti-VIP antibodies showed that some of the NADPH-d-positive cells in the myenteric and submucosal ganglia also contained VIP-LI, but all VIP-LI-positive cells did not express NADPH-d activity. These data are consistent with recent physiological studies suggesting that nitric oxide serves as an inhibitory neurotransmitter in the pyloric and ileocolonic sphincters. The data also suggest that VIP is expressed in a sub-population of NADPH-d-positive neurons and may therefore act as a co-transmitter in enteric inhibitory neurotransmission to these specialized muscular regions.
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Registered trials
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