ArticleProceedings of the National Academy of Sciences of the United States of America1994
Ca2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium.The Journal of physiology · 2023Article
- Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk.JACC. Basic to translational science · 2017Article
- Modulation of Local and Systemic Heterocellular Communication by Mechanical Forces: A Role of Endothelial Nitric Oxide Synthase.Antioxidants & redox signaling · 2017Review
- Article
- Materials as stem cell regulators.Nature materials · 2014Review
- Mechanical control of cation channels in the myogenic response.American journal of physiology. Heart and circulatory physiology · 2011Article
- Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels.American journal of physiology. Heart and circulatory physiology · 2010Article
- Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery.British journal of pharmacology · 2009Review
- Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines.Pflugers Archiv : European journal of physiology · 2008Article
- Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Intracellular Na(+) modulates large conductance Ca(2+)-activated K (+) currents in human umbilical vein endothelial cells.Pflugers Archiv : European journal of physiology · 2008Article
- Characterization of single L-type Ca2+ channels in myocytes isolated from the cricket lateral oviduct.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2005Article
- Ca(2+)- and voltage-dependent gating of Ca(2+)- and ATP-sensitive cationic channels in brain capillary endothelium.Biophysical journal · 2003Article
- Shear stress regulates the endothelial Kir2.1 ion channel.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Mechanosensitive cation channels in human leukaemia cells: calcium permeation and blocking effect.The Journal of physiology · 2002Article
- Visualization of Ca2+ entry through single stretch-activated cation channels.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Stretch-dependent potassium channels in murine colonic smooth muscle cells.The Journal of physiology · 2001Article
- Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Stretch-activated and background non-selective cation channels in rat atrial myocytes.The Journal of physiology · 2000Article
- Activation of Na+-permeant cation channel by stretch and cyclic AMP-dependent phosphorylation in renal epithelial A6 cells.The Journal of general physiology · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The endocardial endothelium is an important modulator of myocardial function. The present study demonstrates the existence of a stretch-activated Ca(2+)-permeable cation channel and of a Ca(2+)-activated K+ channel in the endocardial endothelium of the porcine right atrium. The stretch-activated channel is permeable for K+, Na+, Ca2+, and Ba2+, with mean conductances of approximately 32 pS for the monovalent cations and approximately 13 pS for divalent cations. The Ca(2+)-activated K+ channel has a mean conductance of 192 pS in symmetrical KCl. solution. Channel activity is strongly dependent on membrane potential and the cytosolic Ca2+ concentration. Half-maximal activation occurs at a cytosolic Ca2+ concentration of approximately 5 microM. The influx of Ca2+ through the stretch-activated channel is sufficient to activate the Ca(2+)-activated K+ channel in cell-attached patches. Upon activation of the stretch-activated channel, the cytosolic Ca2+ concentration increases, at least locally, to values of approximately 0.5 microM, as deduced from the open probability of the Ca(2+)-dependent K+ channel that was activated simultaneously. The stretch-activated channels are capable of inducing an intracellular Ca2+ signal and may have a role as mechanosensors in the atrial endothelium, possibly activated by atrial overload.
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