ArticleThe Journal of clinical investigation1994
Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocytosis in experimental meningitis in the rabbit.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 127 citations in OpenAlex.
- Effectiveness of papaverine cisternal irrigation for cerebral vasospasm after aneurysmal subarachnoid hemorrhage and measurement of biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Trial
- Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level.Frontiers in immunology · 2023Article
- Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier.Frontiers in immunology · 2022Article
- Regulation of LOX-1 on adhesion molecules and neutrophil infiltration in mouseInternational journal of ophthalmology · 2020Article
- Anticoagulant Activity of Sulfated Ulvan Isolated from the Green MacroalgaMarine drugs · 2019Article
- Agomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Model.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Fucoidan as a marine anticancer agent in preclinical development.Marine drugs · 2014Review
- Clusterin facilitates in vivo clearance of extracellular misfolded proteins.Cellular and molecular life sciences : CMLS · 2011Article
- Pathogenesis and pathophysiology of pneumococcal meningitis.Clinical microbiology reviews · 2011Review
- Fucoidan enhances the survival and sustains the number of splenic dendritic cells in mouse endotoxemia.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2011Article
- Chemical structures and bioactivities of sulfated polysaccharides from marine algae.Marine drugs · 2011Review
- Leukocyte extravasation: an immunoregulatory role for alpha-L-fucosidase?Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway.British journal of pharmacology · 2008Article
- TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1.Neurochemistry international · 2008Article
- Successful downstream application of the Paxgene Blood RNA system from small blood samples in paediatric patients for quantitative PCR analysis.BMC immunology · 2007Article
- Increased diffusion of soluble adhesion molecules in meningitis, severe sepsis and systemic inflammatory response without neurological infection is associated with intrathecal shedding in cases of meningitis.Intensive care medicine · 2004Article
- A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.The American journal of pathology · 2003Article
- Reprogramming the host response in bacterial meningitis: how best to improve outcome?Clinical microbiology reviews · 2003Review
- Serum concentration of adhesion molecules in patients with delayed ischaemic neurological deficit after aneurysmal subarachnoid haemorrhage: the immunoglobulin and selectin superfamilies.Journal of neurology, neurosurgery, and psychiatry · 2001Article
- Hypothermia attenuates beta1 integrin expression on extravasated neutrophils in an animal model of meningitis.Inflammation · 2001Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory recruitment of leukocytes into the cerebrospinal fluid (CSF) during bacterial meningitis has been shown to contribute significantly to the neurological damage commonly associated with this serious disease. In this study we tested whether or not inhibition of leukocyte rolling, a precondition for firm leukocyte adhesion to vascular endothelium in vivo, may reduce CSF leukocyte recruitment and associated inflammatory changes in rabbits with experimental meningitis. As documented by intravital microscopy of small venules in the rabbit mesentery and tenuissimus muscle, leukocyte rolling was rapidly and profoundly reduced by intravenous treatment with the polysaccharide fucoidin, a homopolymer of sulfated L-fucose known to block the function of the leukocytic "rolling receptor" L-selectin. Moreover, fucoidin treatment dramatically reduced the accumulation of both leukocytes and plasma protein in the CSF of rabbits challenged intrathecally with pneumococcal antigen. These main findings thus illustrate that inhibition of leukocyte rolling, an early and obligatory step in the process of leukocyte extravasation, may be an effective therapeutic approach to attenuate leukocyte-dependent central nervous system damage in bacterial meningitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.